Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ACSL1 | P33121 | 2/20 | 0.47 |
| ▸ | ACSL6 | Q9UKU0 | 2/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969195 | 0.77 | TSHR (0.43) | LMNAHPGDPTGS2MAPTALDH1A1 | |
| SCHEMBL3971634 | 0.77 | PTGS2 (0.45) | PTGS2ALDH1A1L3MBTL1GAA | |
| SCHEMBL3971665 | 0.73 | PTPN1 (0.45) | LMNAPTGER4KDM4EHPGDNPSR1 | |
| SCHEMBL7812629 | 0.73 | ACSL1 (0.77) | LMNAACSL1ACSL6PTGER4NPSR1 | |
| SCHEMBL26717425 | 0.69 | PTGS2 (0.54) | KDM4ENPSR1PTGS2MAPTALDH1A1 | |
| SCHEMBL8164337 | 0.67 | TSHR (0.57) | HPGDPTGS2ALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL11993095 | 0.67 | LMNA (0.47) | LMNAPTGER4KDM4EHPGDNPSR1 | |
| SCHEMBL20322862 | 0.67 | LMNA (1.00) | LMNAACSL1ACSL6PTGER4KDM4E | |
| SCHEMBL4276529 | 0.66 | TSHR (0.54) | LMNAKDM4EHPGDPTGS2MAPT | |
| SCHEMBL3976050 | 0.66 | LMNA (0.46) | LMNAACSL1ACSL6PTGER4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7491747-B2 | 4-(Arylthio)- or (4-heteroarylthio)butyric acid derivatives that may be used in the treatment of dyslipidaemia, atherosclerosis and diabetes | MERCK PATENT GMBH (DE) | 2009-02-17 | — | — | US | disclosed |
| US-20050020651-A1 | Butyric acid derivatives | MERCK PATENT GMBH (DE) | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020651-A1 | Butyric acid derivatives | GPR119, DBI, GABRB1 | LMNA 743/4885ACSL1 33/4885ACSL6 128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.