Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.63 |
| ▸ | MAPT | P10636 | 6/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16407670 | 0.82 | PSMD14 (0.53) | KDM4EMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL29862716 | 0.82 | SLC40A1 (0.50) | KDM4EMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL6600225 | 0.82 | LTA4H (0.58) | KDM4EMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL13625118 | 0.82 | SLC40A1 (0.50) | KDM4EMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL10333926 | 0.81 | KDM4E (0.57) | KDM4EMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL10650819 | 0.80 | PKM (0.62) | KDM4EMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL16364141 | 0.80 | KDM4E (0.59) | KDM4EMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL17960047 | 0.79 | SLC40A1 (0.54) | KDM4EMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL28594857 | 0.78 | LIPE (0.55) | KDM4EMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL8346630 | 0.78 | NPC1 (0.55) | KDM4EMAPTALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2056823-A2 | 8-HYDROXYQUINOLINE COMPOUNDS AND METHODS THEREOF | Wyeth (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008024922-A2 | 8-HYDROXYQUINOLINE COMPOUNDS AND METHODS THEREOF | WYETH (US) | 2008-02-28 | — | — | WO | disclosed |
| US-5817520-A | USING A QUINOLINIUM INDICATOR | OXIS INTERNATIONAL S.A. (FR) | 1998-10-06 | — | — | US | disclosed |
| EP-0643698-B1 | SPECTROPHOTOMETRIC METHODS FOR ASSAYING TOTAL MERCAPTANS, REDUCED GLUTATHIONE (GSH) AND MERCAPTANS OTHER THAN GSH IN AN AQUEOUS MEDIUM, REAGENTS AND KITS FOR THEIR IMPLEMENTATION | OXIS INT SA (FR) | 1997-03-05 | — | — | EP | disclosed |
| EP-0643698-A1 | SPECTROPHOTOMETRIC METHODS FOR ASSAYING TOTAL MERCAPTANS, REDUCED GLUTATHIONE (GSH) AND MERCAPTANS OTHER THAN GSH IN AN AQUEOUS MEDIUM, REAGENTS AND KITS FOR IMPLEMENTING SAME. | BIOXYTECH (FR) | 1995-03-22 | — | — | EP | disclosed |
| WO-1993013071-A1 | SPECTROPHOTOMETRIC METHODS FOR ASSAYING TOTAL MERCAPTANS, REDUCED GLUTATHIONE (GSH) AND MERCAPTANS OTHER THAN GSH IN AN AQUEOUS MEDIUM, REAGENTS AND KITS FOR IMPLEMENTING SAME | BIOXYTECH (FR) | 1993-07-08 | — | — | WO | disclosed |