Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ribose (Furanose). The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | THPO | P40225 | 1/20 | 0.54 |
| ▸ | MTOR | P42345 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | HBB | P68871 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | PYGM | P11217 | 3/20 | 0.38 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.37 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.37 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.37 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | PNP | P00491 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | TK2 | O00142 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ribose (Furanose) SCHEMBL2056776 | 1.00 | LMNA (0.54) | LMNASMN1; SMN2ALDH1A1MAPTCYP19A1 | |
| Ribose (Furanose) SCHEMBL5521544 | 0.83 | ATAD2 (0.54) | LMNAALDH1A1PYGMSLC28A1SLC28A2 | |
| Ribose (Furanose) SCHEMBL27814247 | 0.83 | DPYD (0.54) | LMNAALDH1A1MAPTPYGMSLC28A1 | |
| Ribose (Furanose) SCHEMBL1851842 | 0.83 | ATAD2 (0.54) | LMNAALDH1A1PYGMSLC28A1SLC28A2 | |
| D-Galactose SCHEMBL16581344 | 0.82 | ATAD2 (0.53) | ALDH1A1PYGMATM | |
| Dextrose SCHEMBL6692229 | 0.82 | ATAD2 (0.53) | ALDH1A1PYGMATM | |
| Ribose (Furanose) SCHEMBL9621710 | 0.82 | SLC5A2 (0.39) | ALDH1A1PYGMSLC28A1SLC28A2SLC29A1 | |
| 5-Fluorouridine SCHEMBL6441323 | 0.81 | PYGM (0.60) | LMNASMN1; SMN2MAPTTSHRHBB | |
| Fluorouracil SCHEMBL8778444 | 0.80 | LMNA (0.51) | LMNASMN1; SMN2ALDH1A1MAPTCYP19A1 | |
| Fluorouracil SCHEMBL4289411 | 0.80 | LMNA (0.50) | LMNASMN1; SMN2ALDH1A1MAPTCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104398519-A | Advanced cancer treatment method | FENG BAOZHANG | 2015-03-11 | — | — | CN | disclosed |
| WO-2009058800-A2 | SYNTHESIS OF NUCLEOSIDES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-05-07 | — | — | WO | disclosed |
| US-20050079222-A1 | Production of nanoparticles from methyl vinyl ether and maleic anhydride for the administration of hydrophilic pharmaceuticals, more particularly of puric and pyrimidinic bases | INSTITUTO CIENTIFICO Y TECNOLOGICO DE NAVARRA, S.A. (ES) | 2005-04-14 | — | — | US | disclosed |
| EP-1369110-A1 | PRODUCTION OF NANOPARTICLES FROM METHYL VINYL ETHER COPOLYMER AND MALEIC ANHYDRIDE FOR THE ADMINISTRATION OF HYDROPHILIC PHARMACEUTICALS, MORE PARTICULARLY OF PURIC AND PYRIMIDINIC BASES | INSTITUTO CIENTIFICO Y TECNOLOGICO DE NAVARRA, S.A. (ES) | 2003-12-10 | — | — | EP | disclosed |
| EP-0630904-A1 | NOVEL NICOTINE DERIVATIVE | JAPAN TOBACCO INC. (JP) | 1994-12-28 | — | — | EP | disclosed |
| EP-0628567-A1 | NICOTINE DERIVATIVE | JAPAN TOBACCO INC. (JP) | 1994-12-14 | — | — | EP | disclosed |
| US-3879260-A | Process for production of ribosides of nucleic acid base derivatives and analogues thereof | ASAHI CHEMICAL IND | 1975-04-22 | — | — | US | disclosed |