Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 19/20 | 0.57 |
| ▸ | GGPS1 | O95749 | 8/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.55 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9333595 | 0.94 | FDPS (0.61) | FDPSGGPS1PDE3AAGTR1OPRM1 | |
| SCHEMBL16091938 | 0.92 | FDPS (0.62) | FDPSGGPS1PDE3AAGTR1OPRM1 | |
| SCHEMBL9333367 | 0.92 | FDPS (0.62) | FDPSGGPS1PDE3AAGTR1OPRM1 | |
| SCHEMBL11952578 | 0.90 | FDPS (0.47) | FDPSGGPS1PDE3AAGTR1OPRM1 | |
| SCHEMBL10602953 | 0.87 | FDPS (0.47) | FDPSGGPS1PDE3AAGTR1OPRM1 | |
| Olpadronic Acid SCHEMBL138988 | 0.86 | FDPS (0.58) | FDPSGGPS1PDE3AAGTR1OPRM1 | |
| Olpadronic Acid SCHEMBL232124 | 0.84 | FDPS (0.56) | FDPSGGPS1PDE3AAGTR1OPRM1 | |
| Olpadronic Acid SCHEMBL7457593 | 0.83 | FDPS (0.71) | FDPSGGPS1PDE3AAGTR1OPRM1 | |
| SCHEMBL18330273 | 0.82 | FDPS (0.47) | FDPSGGPS1PDE3AAGTR1OPRM1 | |
| SCHEMBL8055487 | 0.82 | FDPS (0.44) | FDPSGGPS1PDE3AAGTR1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 127 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622567-B1 | ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF | MERCK SHARP & DOHME (US) | 2013-07-24 | — | — | EP | claimed |
| US-20060241107-A1 | Androgen receptor modulators and methods of use thereof | MERCK SHARP & DOHME LLC | 2006-10-26 | — | — | US | claimed |
| US-7011847-B2 | Enteric coated formulation for bisphosphonic acids and salts thereof | U & I PHARMACEUTICALS LTD. (US) | 2006-03-14 | — | — | US | claimed |
| EP-1251857-B1 | PHARMACEUTICAL PARENTERAL COMPOSITION CONTAINING A BISPHOSPHONATE | HOFFMANN LA ROCHE (CH) | 2006-02-22 | — | — | EP | claimed |
| EP-1566177-A1 | The use of bisphosphonates for treating skin by stimulating of collagen synthesis | Tigen Biotech Co., Ltd. (KR) | 2005-08-24 | — | — | EP | claimed |
| US-20040198717-A1 | Androgen receptor modulators and methods of use thereof | MERCK SHARP & DOHME CORP. | 2004-10-07 | — | — | US | claimed |
| US-20040161460-A1 | Enteric coated formulation for bisphosphonic acids and salts thereof | U & I PHARMACEUTICALS LTD. (US) | 2004-08-19 | — | — | US | claimed |
| US-20040137056-A1 | Wet granulation formulation for bisphosphonic acids | KATDARE ASHOK V (US) | 2004-07-15 | — | — | US | claimed |
| US-6692764-B2 | TREATMENT AND PREVENTION OF DISEASES INVOLVING BONE RESORPTION, ESPECIALLY OSTEOPOROSIS, PAGET'S DISEASE, MALIGNANT HYPERCALCEMIA, AND METASTATIC BONE DISEASE; BINDER-FREE TABLETS | MERCK & CO., INC. | 2004-02-17 | — | — | US | claimed |
| US-6677320-B2 | MIXTURE WITH CHELATE COMPOUND; BONE DISORDERS | HOFFMANN-LA ROCHES INC. | 2004-01-13 | — | — | US | claimed |
| WO-1995029679-A1 | WET GRANULATION FORMULATION FOR BISPHOSPHONIC ACIDS | MERCK & CO., INC. (US) | 1995-11-09 | — | — | WO | claimed |
| US-5358941-A | Treatment of bone disorders, osteoporosis | MERCK & CO., INC. (US) | 1994-10-25 | — | — | US | claimed |
| WO-1994012200-A1 | DRY MIX FORMULATION FOR BISPHOSPHONIC ACIDS | MERCK & CO., INC. (US) | 1994-06-09 | — | — | WO | claimed |
| EP-0401243-A1 | MEDICINAL PREPARATIONS CHARACTERIZED BY A COMBINATION OF CYTOSTATIC AGENTS, HORMONAL THERAPEUTIC AGENTS AND PHOSPHONE DERIVATIVES. | HENKEL KGAA (DE) | 1990-12-12 | — | — | EP | claimed |
| WO-1989007453-A1 | MEDICINAL PREPARATIONS CHARACTERIZED BY A COMBINATION OF CYTOSTATIC AGENTS, HORMONAL THERAPEUTIC AGENTS AND PHOSPHONE DERIVATIVES | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1989-08-24 | — | — | WO | claimed |
| EP-0175315-B1 | 4-DIMETHYLAMINO-1-HYDROXYBUTANE-1,1-DIPHOSPHONIC ACID, ITS WATER SOLUBLE SALTS, PROCESS FOR THEIR PREPARATION AND ITS USE | Henkel Kommanditgesellschaft auf Aktien (DE) | 1989-01-11 | — | — | EP | claimed |
| EP-0276288-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING A BISPHOSPHONATE AND THEIR USE FOR NASAL ADMINISTRATION | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 1988-08-03 | — | — | EP | claimed |
| WO-1988000829-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING A BISPHOSPHONATE AND THEIR USE FOR NASAL ADMINISTRATION | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LØVENS KEMIS (DK) | 1988-02-11 | — | — | WO | claimed |
| US-4624947-A | CALCIUM BINDING AGENT | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1986-11-25 | — | — | US | claimed |
| EP-0175315-A2 | 4-Dimethylamino-1-hydroxybutane-1,1-diphosphonic acid, its water soluble salts, process for their preparation and its use | Henkel Kommanditgesellschaft auf Aktien (DE) | 1986-03-26 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241107-A1 | Androgen receptor modulators and methods of use thereof | SHBG, FSHR, AR | FDPS 2372/4885GGPS1 577/4885PDE3A 1170/4885 |
| US-20040198717-A1 | Androgen receptor modulators and methods of use thereof | AR, SHBG, FSHR | FDPS 2793/4885GGPS1 797/4885PDE3A 1024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.