Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SSTR5 | P35346 | 3/20 | 0.36 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3970028 | 0.91 | ALDH1A1 (0.37) | MAPTSMN1; SMN2TACR1ALDH1A1HTT | |
| SCHEMBL3977756 | 0.91 | REN (0.41) | MAPTSMN1; SMN2TACR1ALDH1A1HTT | |
| SCHEMBL3972620 | 0.91 | TACR1 (0.38) | TACR1SSTR5SSTR1HRH1SLC6A2 | |
| SCHEMBL3968604 | 0.86 | SSTR5 (0.40) | SMN1; SMN2TACR1ALDH1A1HTTSSTR5 | |
| SCHEMBL3972591 | 0.85 | REN (0.43) | SMN1; SMN2TACR1KDM4E | |
| SCHEMBL3977977 | 0.84 | SSTR5 (0.38) | SMN1; SMN2TACR1ALDH1A1HTTSSTR5 | |
| SCHEMBL3974580 | 0.84 | REN (0.41) | TACR1ALDH1A1SLC6A2SLC6A4POLB | |
| SCHEMBL3972940 | 0.83 | ALOX15 (0.40) | MAPTSLC6A2SLC6A4KDM4E | |
| SCHEMBL3968591 | 0.83 | GAA (0.38) | TACR1ALDH1A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3977983 | 0.81 | SSTR5 (0.41) | MAPTTACR1SSTR5SSTR1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | claimed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | claimed |
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | disclosed |