SCHEMBL397863

SCHEMBL397863

Nc1ccccc1-c1ccccc1F

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.68
L3MBTL1 Q9Y468 1/20 0.68
KDM4E B2RXH2 2/20 0.52
HSD17B10 Q99714 1/20 0.50
KCNN4 O15554 1/20 0.47
MPL P40238 1/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
CYP3A4 P08684 1/20 0.45
ALOX15 P16050 1/20 0.45
CASP1 P29466 1/20 0.45
CASP7 P55210 1/20 0.45
IDO1 P14902 5/20 0.42
NOTUM Q6P988 1/20 0.42
ADORA2A P29274 1/20 0.41
BACE1 P56817 1/20 0.39
MAPT P10636 1/20 0.39
PDE3B Q13370 1/20 0.39
PDE3A Q14432 1/20 0.39
ALOX5AP P20292 1/20 0.39
FEN1 P39748 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25009045 0.85 ALDH1A1 (0.52) ALDH1A1L3MBTL1KDM4EHSD17B10KCNN4
SCHEMBL3644248 0.83 ALDH1A1 (0.46) ALDH1A1L3MBTL1KDM4EHSD17B10KCNN4
SCHEMBL15365758 0.83 ALDH1A1 (0.46) ALDH1A1L3MBTL1KDM4EHSD17B10KCNN4
SCHEMBL3790468 0.83 ALDH1A1 (0.59) ALDH1A1L3MBTL1KDM4EHSD17B10KCNN4
SCHEMBL398474 0.83 ALDH1A1 (0.59) ALDH1A1L3MBTL1KDM4EHSD17B10KCNN4
SCHEMBL169281 0.83 ALDH1A1 (1.00) ALDH1A1L3MBTL1KDM4EHSD17B10SMN1; SMN2
SCHEMBL31607672 0.83 ALDH1A1 (1.00) ALDH1A1L3MBTL1KDM4EHSD17B10SMN1; SMN2
SCHEMBL29547174 0.83 ACHE (0.47) ALDH1A1L3MBTL1KDM4EMPLSMN1; SMN2
SCHEMBL197834 0.83 ACHE (0.47) ALDH1A1L3MBTL1KDM4EMPLSMN1; SMN2
SCHEMBL2845323 0.81 PTPRC (0.50) ALDH1A1L3MBTL1KDM4EHSD17B10KCNN4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 105 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109942433-A A kind of chemical synthesis process of 3 ', 4 ', 5 '-three fluoro- 2- aminobphenyls 浙江工业大学 2019-06-28 CN claimed
CN-107628956-A The method of one kind synthesis aminobphenyl of 3,4 difluoro 2 ' 江西天宇化工有限公司 2018-01-26 CN claimed
EP-1252140-B1 PYRROLECARBOXAMIDES AND PYRROLETHIOAMIDES AS FUNGICIDES SYNGENTA PARTICIPATIONS AG (CH) 2009-05-13 EP claimed
US-20090011935-A1 Method of Inducing Tolerance of Plants Against Bacterioses BASF SE (DE) 2009-01-08 US claimed
EP-1996018-A2 METHOD OF INDUCING TOLERANCE OF PLANTS AGAINST BACTERIOSES BASF SE (DE) 2008-12-03 EP claimed
WO-2007104658-A2 METHOD OF INDUCING TOLERANCE OF PLANTS AGAINST BACTERIOSES BASF SE (DE) 2007-09-20 WO claimed
US-11834459-B2 Host materials for electroluminescent devices UNIVERSAL DISPLAY CORPORATION (US) 2023-12-05 US disclosed
US-11834459-B2 Host materials for electroluminescent devices UNIVERSAL DISPLAY CORPORATION (US) 2023-12-05 US disclosed
US-11834459-B2 Host materials for electroluminescent devices UNIVERSAL DISPLAY CORPORATION (US) 2023-12-05 US disclosed
CN-116891498-A Organic electroluminescent material and device 环球展览公司 2023-10-17 CN disclosed
US-20230329089-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-10-12 US disclosed
US-20230329089-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-10-12 US disclosed
US-20230329089-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-10-12 US disclosed
WO-2007104658-A2 METHOD OF INDUCING TOLERANCE OF PLANTS AGAINST BACTERIOSES BASF SE (DE) 2007-09-20 WO disclosed
US-20060074075-A1 including cystic fibrosis transmembrane conductance regulator (\"CFTR\"), used for treating genetic disorders; respiratory system disorders VERTEX PHARMACEUTICALS INCORPORATED 2006-04-06 US disclosed
CN-1646494-A Disubstituted pyrazolyl carboxanilides BAYER CROPSCIENCE AG (DE) 2005-07-27 CN disclosed
EP-0536151-B1 ORTHOSUBSTITUTED BIPHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM BOOTS CO PLC (GB) 1994-09-14 EP disclosed
US-5302720-A Biphenyl-substituted guanidine derivatives useful as hypoglycaemic agents THE BOOTS COMPANY (GB) 1994-04-12 US disclosed
WO-1992000273-A1 ORTHOSUBSTITUTED BIPHENYL AMIDINE AND BIPHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM THE BOOTS COMPANY PLC (GB) 1992-01-09 WO disclosed
EP-0387802-A2 5-Substituted-1,4-dihydro-4-oxonaphthyridine-3-carboxylate antibacterial agents Bristol-Myers Squibb Company (US) 1990-09-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090011935-A1 Method of Inducing Tolerance of Plants Against Bacterioses BROX, CAT, SLC11A2 ALDH1A1 2207/4885L3MBTL1 417/4885KDM4E 4657/4885
US-20230329089-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES NR1H2, OXER1, NR1H3 ALDH1A1 669/4885L3MBTL1 2221/4885KDM4E 2635/4885
US-11834459-B2 Host materials for electroluminescent devices RPS4X, MLX, RPS4Y1 ALDH1A1 4129/4885L3MBTL1 2433/4885KDM4E 1801/4885
US-20060074075-A1 including cystic fibrosis transmembrane conductance regulator (\"CFTR\"), used for treating genetic disorders; respiratory system disorders CFTR, ABCC4, ABCC2 ALDH1A1 2221/4885L3MBTL1 3693/4885KDM4E 4649/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.