Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPN | P05981 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2634714 | 1.00 | HPN (0.49) | HPNMEN1MAPTKMT2AHTR1A | |
| SCHEMBL4259265 | 0.87 | ALDH1A1 (0.44) | HPNMEN1MAPTKMT2AHTR1A | |
| SCHEMBL3975843 | 0.82 | SIRT6 (0.59) | MAPTHTR1AHTR7ALDH1A1SCN2A | |
| SCHEMBL3977939 | 0.82 | ALDH1A1 (0.47) | MEN1MAPTKMT2AALDH1A1LMNA | |
| SCHEMBL10745684 | 0.81 | HPN (0.53) | HPNMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL11819105 | 0.81 | HPN (0.55) | HPNMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL3223479 | 0.78 | KMT2A (0.61) | HPNMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL27906471 | 0.78 | HTR1A (0.60) | HPNMEN1MAPTKMT2AHTR1A | |
| SCHEMBL1583660 | 0.78 | POLB (0.49) | MEN1MAPTKMT2AHTR1AHTR7 | |
| SCHEMBL519878 | 0.78 | HTR1A (0.72) | HPNMEN1MAPTKMT2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907385-A4 | COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-05-06 | — | — | EP | disclosed |
| EP-1907385-A2 | COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007018941-A2 | PYRIMIDYL-THIOPHENE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-15 | — | — | WO | disclosed |