Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 6/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30998103 | 0.91 | MAPT (0.55) | ALDH1A1MAPTLMNAMETENPP2 | |
| SCHEMBL5119617 | 0.91 | MAPT (0.55) | ALDH1A1MAPTLMNAMETENPP2 | |
| SCHEMBL3978819 | 0.82 | HPN (0.49) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL2634714 | 0.82 | HPN (0.49) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL5093442 | 0.79 | MAPT (0.70) | ALDH1A1MAPTLMNA | |
| SCHEMBL4259265 | 0.79 | ALDH1A1 (0.44) | ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL1583541 | 0.78 | HPGDS (0.48) | ENPP2USP30 | |
| SCHEMBL5891913 | 0.77 | P2RX7 (0.58) | MAPTENPP2USP30MEN1KMT2A | |
| SCHEMBL22650344 | 0.77 | NR1H2 (0.53) | ALDH1A1MAPTLMNAMAPK1USP30 | |
| SCHEMBL985189 | 0.77 | LMNA (0.73) | ALDH1A1MAPTLMNAMETENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907385-A4 | COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-05-06 | — | — | EP | disclosed |
| EP-1907385-A2 | COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007018941-A2 | PYRIMIDYL-THIOPHENE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-15 | — | — | WO | disclosed |