Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HPN | P05981 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3971995 | 0.90 | ALDH1A1 (0.52) | ALDH1A1KDM4ETDP1MEN1MAPT | |
| SCHEMBL3978819 | 0.87 | HPN (0.49) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL2634714 | 0.87 | HPN (0.49) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL4256391 | 0.85 | ALDH1A1 (0.47) | ALDH1A1KDM4ETDP1MEN1MAPT | |
| SCHEMBL3977939 | 0.79 | ALDH1A1 (0.47) | ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL4079481 | 0.76 | SIRT6 (0.44) | ALDH1A1KDM4ETDP1MEN1MAPT | |
| SCHEMBL2634258 | 0.75 | BCL2A1 (0.52) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL3974009 | 0.72 | DDB1 (0.46) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL2634327 | 0.72 | MAPT (0.51) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL4255218 | 0.72 | ALDH1A1 (0.46) | ALDH1A1KDM4ETDP1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907385-A4 | COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-05-06 | — | — | EP | disclosed |
| EP-1907385-A2 | COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007018941-A2 | PYRIMIDYL-THIOPHENE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-15 | — | — | WO | disclosed |