Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 2/20 | 0.65 |
| ▸ | CDC7 | O00311 | 9/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | MMP14 | P50281 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.48 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.47 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7997890 | 0.86 | ALDH1A1 (0.56) | GCGRALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL28411840 | 0.86 | GCGR (0.51) | GCGRCDC7CASP1ALDH1A1HPGD | |
| SCHEMBL7500235 | 0.85 | LMNA (0.54) | GCGRMAPK14ALDH1A1HPGDHSD17B10 | |
| SCHEMBL4182065 | 0.85 | GCGR (0.86) | GCGRCDC7CASP1MAPK14MMP2 | |
| SCHEMBL4174038 | 0.85 | GCGR (0.66) | GCGRCDC7CASP1MAPK14MMP2 | |
| SCHEMBL4190717 | 0.84 | GCGR (0.72) | GCGRCDC7CASP1MAPK14MMP2 | |
| SCHEMBL15305092 | 0.84 | GCGR (0.65) | GCGRCDC7CASP1MAPK14ALDH1A1 | |
| SCHEMBL6268999 | 0.84 | MEN1 (0.51) | GCGRCDC7ALDH1A1HSD17B10MEN1 | |
| SCHEMBL18342044 | 0.84 | MEN1 (0.55) | GCGRCDC7MAPK14ALDH1A1HPGD | |
| SCHEMBL4099274 | 0.84 | GCGR (0.53) | GCGRCDC7CASP1ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230271932-A1 | SMALL MOLECULE COVALENT ACTIVATORS OF UCP1 | DANA FARBER CANCER INST INC (US) | 2023-08-31 | — | — | US | disclosed |
| US-20230271932-A1 | SMALL MOLECULE COVALENT ACTIVATORS OF UCP1 | DANA FARBER CANCER INST INC (US) | 2023-08-31 | — | — | US | disclosed |
| US-20230271932-A1 | SMALL MOLECULE COVALENT ACTIVATORS OF UCP1 | DANA FARBER CANCER INST INC (US) | 2023-08-31 | — | — | US | disclosed |
| US-20090118276-A1 | THIENOPYRIMIDINES, THIENOPYRIDINES, AND PYRROLOPYRIMIDINES AS B-RAF INHIBITORS | WYETH (US) | 2009-05-07 | — | — | US | disclosed |
| WO-2009059272-A1 | THIENOPYRIMIDINES, THIENOPYRIDINES, AND PYRROLOPYRIMIDINES AS B-RAF INHIBITORS | WYETH (US) | 2009-05-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118276-A1 | THIENOPYRIMIDINES, THIENOPYRIDINES, AND PYRROLOPYRIMIDINES AS B-RAF INHIBITORS | BRAF, ARAF, RAF1 | GCGR 1593/4885CDC7 704/4885CASP1 3684/4885 |
| US-20230271932-A1 | SMALL MOLECULE COVALENT ACTIVATORS OF UCP1 | PC, FABP4, PCK2 | GCGR 267/4885CDC7 1828/4885CASP1 1863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.