Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP2 | Q6P179 | 7/20 | 0.62 |
| ▸ | IL1RN | P18510 | 6/20 | 0.57 |
| ▸ | ERAP1 | Q9NZ08 | 4/20 | 0.57 |
| ▸ | MMP2 | P08253 | 5/20 | 0.53 |
| ▸ | MMP9 | P14780 | 4/20 | 0.53 |
| ▸ | MMP8 | P22894 | 4/20 | 0.53 |
| ▸ | MMP1 | P03956 | 3/20 | 0.53 |
| ▸ | EDNRA | P25101 | 1/20 | 0.52 |
| ▸ | GHSR | Q92847 | 1/20 | 0.50 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.49 |
| ▸ | ADAM12 | O43184 | 1/20 | 0.49 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.49 |
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
| ▸ | MMP7 | P09237 | 1/20 | 0.49 |
| ▸ | MMP12 | P39900 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | MMP14 | P50281 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3904013 | 0.87 | ERAP2 (0.63) | ERAP2IL1RNERAP1MMP2MMP9 | |
| SCHEMBL3904009 | 0.87 | ERAP2 (0.63) | ERAP2IL1RNERAP1MMP2MMP9 | |
| SCHEMBL2197039 | 0.84 | ERAP2 (0.61) | ERAP2IL1RNERAP1MMP2MMP9 | |
| SCHEMBL3077916 | 0.83 | ERAP2 (0.56) | ERAP2IL1RNERAP1MMP2MMP9 | |
| SCHEMBL2184049 | 0.82 | ERAP2 (0.58) | ERAP2IL1RNERAP1MMP2MMP9 | |
| SCHEMBL2195263 | 0.82 | KISS1R (0.52) | ERAP2MMP1GHSRKISS1R | |
| SCHEMBL31171653 | 0.82 | CASP1 (0.58) | ERAP2MMP2MMP9MMP8MMP1 | |
| SCHEMBL31388720 | 0.81 | ERAP2 (0.64) | ERAP2IL1RNERAP1EDNRAKISS1R | |
| SCHEMBL30120684 | 0.81 | GHSR (0.59) | ERAP2IL1RNERAP1GHSRKISS1R | |
| SCHEMBL30931483 | 0.81 | ERAP2 (0.66) | ERAP2IL1RNERAP1EDNRAECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1906987-A4 | METHODS AND COMPOSITIONS FOR EMERGENCY CONTRACEPTION USING ENDOTHELIN RECEPTOR ANTAGONISTS | POPULATION COUNCIL INC (US) | 2009-01-28 | — | — | EP | disclosed |
| EP-1906987-A1 | METHODS AND COMPOSITIONS FOR EMERGENCY CONTRACEPTION USING ENDOTHELIN RECEPTOR ANTAGONISTS | The Population Council, Inc. (US) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007012006-A1 | METHODS AND COMPOSITIONS FOR EMERGENCY CONTRACEPTION USING ENDOTHELIN RECEPTOR ANTAGONISTS | THE POPULATION COUNCIL, INC. (US) | 2007-01-25 | — | — | WO | disclosed |