SCHEMBL398137

SCHEMBL398137

Nc1ccc2c(c1)NC(=O)C2

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA9 Q16790 1/20 0.70
AHR P35869 4/20 0.61
CMA1 P23946 2/20 0.61
EIF2AK2 P19525 1/20 0.59
PDK2 Q15119 1/20 0.53
TDP2 O95551 5/20 0.53
KDM4E B2RXH2 1/20 0.50
MEN1 O00255 1/20 0.50
GAA P10253 1/20 0.50
MAPT P10636 1/20 0.50
KMT2A Q03164 1/20 0.50
CRBN Q96SW2 3/20 0.46
KDM1A O60341 1/20 0.46
SMYD3 Q9H7B4 1/20 0.44
CCNB2 O95067 1/20 0.43
CDK1 P06493 1/20 0.43
CCNB1 P14635 1/20 0.43
GSK3B P49841 1/20 0.43
CDK5 Q00535 1/20 0.43
CDK5R1 Q15078 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30468520 1.00 CA9 (0.70) CA9AHRCMA1EIF2AK2PDK2
Hydrochloric Acid SCHEMBL9833199 0.98 CA9 (0.68) CA9AHRCMA1EIF2AK2PDK2
Methylamine SCHEMBL28015139 0.96 CA9 (0.66) CA9AHRCMA1EIF2AK2PDK2
SCHEMBL22660 0.84 AHR (0.61) CA9AHRCMA1EIF2AK2PDK2
SCHEMBL28378777 0.83 MAPT (0.62) CA9AHRCMA1EIF2AK2TDP2
SCHEMBL521524 0.82 CA9 (1.00) CA9KDM4EMEN1GAAMAPT
SCHEMBL29370621 0.82 CA9 (1.00) CA9KDM4EMEN1GAAMAPT
Bromide SCHEMBL9824774 0.82 AHR (0.59) CA9AHRCMA1EIF2AK2PDK2
Hydrochloric Acid SCHEMBL15206761 0.82 AHR (0.59) CA9AHRCMA1EIF2AK2PDK2
SCHEMBL2616913 0.82 TDP2 (0.54) CA9AHRCMA1EIF2AK2PDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 306 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110230478-A1 4-Alkyl-substituted diaminopyrimidines Bayer ScienceCrop AG (DE) 2011-09-22 US claimed
EP-2330904-A2 4-ALKYL-SUBSTITUTED DIAMINOPYRIMIDINES Bayer CropScience AG (DE) 2011-06-15 EP claimed
US-20110105472-A1 Diaminopyrimidines as crop protection agents BAYER CROPSCIENCE AG (DE) 2011-05-05 US claimed
EP-2268144-A2 DIAMINOPYRIMIDINES AS PLANT PROTECTION AGENTS Bayer CropScience AG (DE) 2011-01-05 EP claimed
WO-2010025863-A2 4-ALKYL-SUBSTITUTED DIAMINOPYRIMIDINES BAYER CROPSCIENCE AG (DE) 2010-03-11 WO claimed
WO-2010025871-A1 4-HALOGEN ALKYL-SUBSTITUTED DIAMINOPYRIMIDINES FOR USE AS FUNGICIDES BAYER CROPSCIENCE AG (DE) 2010-03-11 WO claimed
EP-2161259-A1 4-Haloalkyl substituted Diaminopyrimidine Bayer CropScience AG (DE) 2010-03-10 EP claimed
WO-2009115267-A2 DIAMINOPYRIMIDINES AS PLANT PROTECTION AGENTS BAYER CROPSCIENCE AG (DE) 2009-09-24 WO claimed
US-12528797-B2 Heterocyclic compounds for medical treatment C4 THERAPEUTICS, INC. 2026-01-20 US disclosed
US-20250320184-A1 SARM1 MODULATORS, PREPARATIONS, AND USES THEREOF SIRONAX LTD (KY) 2025-10-16 US disclosed
US-20250230157-A1 AZABENZIMIDAZOLES AND THEIR USE AS AMPA RECEPTOR MODULATORS RAPPORT THERAPEUTICS, INC. 2025-07-17 US disclosed
US-12304908-B2 Azabenzimidazoles and their use as AMPA receptor modulators RAPPORT THERAPEUTICS, INC. (US) 2025-05-20 US disclosed
WO-2025085819-A1 KINASE INHIBITOR COMPOSITIONS AND RELATED METHODS FOR THE TREATMENT OF A DISEASE WASHINGTON UNIVERSITY (US) 2025-04-24 WO disclosed
EP-4536640-A1 SARM1 MODULATORS, PREPARATIONS, AND USES THEREOF Sironax Ltd. (KY) 2025-04-16 EP disclosed
EP-0549892-A1 Substituted indolinones useful as herbicidal agents AMERICAN CYANAMID COMPANY (US) 1993-07-07 EP disclosed
US-4985448-A Ureidoindoles, pharmaceutical compositions and methods for erythrocyte and thrombocyte aggregation inhibition BOEHRINGER MANNHEIM GMBH (DE) 1991-01-15 US disclosed
EP-0216165-B1 BENZODIPYRROLES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS Roche Diagnostics GmbH (DE) 1989-11-23 EP disclosed
US-4810801-A Pyrrolobenzimidazoles, pharmaceutical compositions containing them, and use of them to treat certain heart and circulatory diseases BOEHRINGER MANNHEIM GMBH (DE) 1989-03-07 US disclosed
US-4710510-A Pyrrolobenzimidazoles, pharmaceutical compositions containing them, and use of them to treat certain heart and circulatory diseases BOEHRINGER MANNHEIM GMBH (DE) 1987-12-01 US disclosed
EP-0216165-A1 Benzodipyrroles, processes for their preparation and pharmaceutical compositions containing these compounds Roche Diagnostics GmbH (DE) 1987-04-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250320184-A1 SARM1 MODULATORS, PREPARATIONS, AND USES THEREOF SARM1, SMN1; SMN2, ADRM1 CA9 4881/4885AHR 4390/4885CMA1 3692/4885
US-12528797-B2 Heterocyclic compounds for medical treatment CRBN, CUL2, ADRM1 CA9 2511/4885AHR 1880/4885CMA1 2057/4885
US-20110230478-A1 4-Alkyl-substituted diaminopyrimidines DPM1, DPYD, POLR1C CA9 2561/4885AHR 504/4885CMA1 991/4885
US-20110105472-A1 Diaminopyrimidines as crop protection agents DDX41, DDX1, DDX5 CA9 1421/4885AHR 2612/4885CMA1 2197/4885
US-12304908-B2 Azabenzimidazoles and their use as AMPA receptor modulators GRIN1, GRIN2B, GRIN3A CA9 3848/4885AHR 2068/4885CMA1 4614/4885
US-20250230157-A1 AZABENZIMIDAZOLES AND THEIR USE AS AMPA RECEPTOR MODULATORS GRIN1, GRIN2B, GRIN3A CA9 3822/4885AHR 2063/4885CMA1 4615/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.