Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 7/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6529415 | 0.85 | LMNA (0.71) | LMNATSHRKMT2AALDH1A1TP53 | |
| SCHEMBL397333 | 0.85 | LMNA (0.51) | LMNATSHRKMT2AALDH1A1TP53 | |
| SCHEMBL9516048 | 0.85 | TSHR (0.57) | LMNATSHRKMT2AALDH1A1TP53 | |
| SCHEMBL11582938 | 0.84 | L3MBTL1 (0.50) | LMNATSHRKMT2AALDH1A1L3MBTL1 | |
| SCHEMBL394260 | 0.83 | LMNA (0.69) | LMNATSHRKMT2AALDH1A1TP53 | |
| SCHEMBL34694 | 0.83 | LMNA (1.00) | LMNATSHRKMT2AALDH1A1TP53 | |
| SCHEMBL1762528 | 0.83 | LMNA (0.54) | LMNATSHRKMT2AALDH1A1MEN1 | |
| SCHEMBL1185864 | 0.83 | LMNA (0.69) | LMNATSHRKMT2AALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL10767073 | 0.82 | L3MBTL1 (0.49) | LMNATSHRKMT2AALDH1A1L3MBTL1 | |
| SCHEMBL27878677 | 0.81 | LMNA (0.67) | LMNATSHRKMT2AALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250388615-A9 | SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS | ARDELYX, INC. (US) | 2025-12-25 | — | — | US | disclosed |
| US-20250066410-A1 | SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS | ARDELYX, INC. (US) | 2025-02-27 | — | — | US | disclosed |
| US-12084472-B2 | Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists | ARDELYX, INC. (US) | 2024-09-10 | — | — | US | disclosed |
| WO-2023208151-A1 | USP INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION | 北京华森英诺生物科技有限公司 | 2023-11-02 | — | — | WO | disclosed |
| CN-116621778-A | USP inhibitor, preparation method and application thereof | 北京华森英诺生物科技有限公司 | 2023-08-22 | — | — | CN | disclosed |
| US-20220306672-A1 | SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS | ARDELYX, INC. (US) | 2022-09-29 | — | — | US | disclosed |
| EP-3390382-B1 | SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS | ARDELYX INC (US) | 2021-12-01 | — | — | EP | disclosed |
| CN-108699028-B | Substituted 4-phenylpyridines as non-systemic TGR5 agonists | 阿德利克斯公司 | 2021-10-22 | — | — | CN | disclosed |
| US-10968246-B2 | Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists | ARDELYX, INC. (US) | 2021-04-06 | — | — | US | disclosed |
| US-10821100-B2 | Triazolone compounds as mPGES-1 inhibitors | Ichnos Sciences SA (CH) | 2020-11-03 | — | — | US | disclosed |
| EP-0113151-A2 | Printing medium and use thereof | International Business Machines Corporation (US) | 1984-07-11 | — | — | EP | disclosed |
| US-4443302-A | Printing medium and use thereof | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 1984-04-17 | — | — | US | disclosed |
| EP-0008072-B1 | SUBSTITUTED ANTHRANILIC ACID AMIDES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PREPARATION | CIBA-GEIGY AG (CH) | 1984-02-22 | — | — | EP | disclosed |
| US-4377521-A | ANTILIPEMIC | PFIZER INC. (US) | 1983-03-22 | — | — | US | disclosed |
| US-4229343-A | Azo dyes from an oxadiazolyl-substituted aniline | BASF AKTIENGESELLSCHAFT (DE) | 1980-10-21 | — | — | US | disclosed |
| EP-0008072-A1 | Substituted anthranilic acid amides, process for their preparation, pharmaceutical compositions containing them and their preparation | CIBA-GEIGY AG (CH) | 1980-02-20 | — | — | EP | disclosed |
| US-4138399-A | Sulfamylbenzoic acid | PFIZER INC. (US) | 1979-02-06 | — | — | US | disclosed |
| US-4124590-A | CARDIOVASCULAR DISORDERS, ANTILIPEMIC AGENTS | PFIZER INC. (US) | 1978-11-07 | — | — | US | disclosed |
| US-3992441-A | ANTILIPEMIC | PFIZER INC. (US) | 1976-11-16 | — | — | US | disclosed |
| US-3954994-A | Intermediates for preparing hipolipemic agents and method of lowering the blood lipid level in mammals with said agents | PFIZER INC. (US) | 1976-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250066410-A1 | SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS | GPR119, GIPR, GLP1R | LMNA 4746/4885TSHR 87/4885KMT2A 3941/4885 |
| US-20250388615-A9 | SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS | GPR119, GIPR, FFAR3 | LMNA 4241/4885TSHR 64/4885KMT2A 4450/4885 |
| US-10968246-B2 | Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists | GPR119, GIPR, GLP1R | LMNA 4746/4885TSHR 87/4885KMT2A 3941/4885 |
| US-20220306672-A1 | SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS | GPR119, GIPR, GLP1R | LMNA 4746/4885TSHR 87/4885KMT2A 3941/4885 |
| US-12084472-B2 | Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists | GPR119, GIPR, GLP1R | LMNA 4746/4885TSHR 87/4885KMT2A 3941/4885 |
| US-10821100-B2 | Triazolone compounds as mPGES-1 inhibitors | PTGES, PTGS1, PTGIS | LMNA 4091/4885TSHR 2179/4885KMT2A 3898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.