Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3985579 | 0.88 | LMNA (0.44) | TDP1KDM4EALDH1A1HPGDPTGDR2 | |
| SCHEMBL3983651 | 0.81 | PTGDR2 (0.43) | TDP1PTGDR2TSHRMAPT | |
| SCHEMBL3984193 | 0.81 | MAPT (0.50) | TDP1KDM4EALDH1A1HPGDLMNA | |
| SCHEMBL3984415 | 0.77 | HTR2C (0.43) | KDM4EALDH1A1HPGDLMNAGAA | |
| SCHEMBL3980996 | 0.70 | PTGDR2 (0.39) | TDP1KDM4EALDH1A1PTGDR2LMNA | |
| SCHEMBL28128957 | 0.70 | KDM4E (0.51) | TDP1KDM4EALDH1A1HPGDPTGDR2 | |
| SCHEMBL3988279 | 0.69 | TDP1 (0.47) | TDP1KDM4EALDH1A1HPGDPTGDR2 | |
| SCHEMBL3778473 | 0.69 | PTGDR2 (0.45) | TDP1KDM4EALDH1A1HPGDPTGDR2 | |
| SCHEMBL7691378 | 0.68 | PTGDR2 (0.55) | TDP1KDM4EALDH1A1HPGDPTGDR2 | |
| SCHEMBL45506 | 0.68 | MAPT (0.68) | TDP1KDM4EALDH1A1HPGDPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009060209-A1 | 6,6-FUSED BICYCLIC AROMATIC COMPOUNDS AND THEIR THERAPEUTI USE | ARGENTA DISCOVERY LIMITED (GB) | 2009-05-14 | — | — | WO | disclosed |
| WO-2009060209-A1 | 6,6-FUSED BICYCLIC AROMATIC COMPOUNDS AND THEIR THERAPEUTI USE | ARGENTA DISCOVERY LIMITED (GB) | 2009-05-14 | — | — | WO | disclosed |