Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3983780 | 0.89 | THRB (0.46) | HTTKDM4ETDP1ALOX5PPARG | |
| SCHEMBL3984196 | 0.81 | MAPT (0.41) | HTTP2RX3KDM4EMAPTKMT2A | |
| SCHEMBL11460802 | 0.70 | NPSR1 (0.57) | HTTP2RX3MAPTPOLBTDP1 | |
| SCHEMBL3985274 | 0.69 | PTGDR2 (0.43) | KDM4EMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL3345503 | 0.69 | P2RX3 (0.42) | P2RX3KDM4EMAPTKMT2AALDH1A1 | |
| SCHEMBL5494773 | 0.68 | KDM4E (0.45) | HTTKDM4EMAPTKMT2AALDH1A1 | |
| SCHEMBL3989733 | 0.68 | LMNA (0.39) | KDM4EKMT2AALDH1A1POLBTDP1 | |
| SCHEMBL3345008 | 0.68 | P2RX3 (0.43) | P2RX3KDM4EMAPTKMT2AALDH1A1 | |
| SCHEMBL3980177 | 0.66 | DAO (0.43) | KDM4EMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL3986256 | 0.66 | TDP1 (0.43) | HTTKDM4EMAPTTDP1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009060209-A1 | 6,6-FUSED BICYCLIC AROMATIC COMPOUNDS AND THEIR THERAPEUTI USE | ARGENTA DISCOVERY LIMITED (GB) | 2009-05-14 | — | — | WO | disclosed |