Anpirtoline

Anpirtoline

SCHEMBL398427

Clc1cccc(SC2CCNCC2)n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 1.00
KMT2A Q03164 3/20 1.00
CYP1A2 P05177 2/20 1.00
HTR3E A5X5Y0 2/20 0.42
HTR3B O95264 2/20 0.42
HTR3A P46098 2/20 0.42
HTR3D Q70Z44 2/20 0.42
HTR3C Q8WXA8 2/20 0.42
ALDH1A1 P00352 1/20 0.42
TSHR P16473 2/20 0.34
CYP2D6 P10635 1/20 0.34
ALOX15 P16050 1/20 0.34
NFKB1 P19838 1/20 0.34
CYP3A4 P08684 1/20 0.32
SLC18A3 Q16572 1/20 0.32
SIGMAR1 Q99720 1/20 0.32
IKBKB O14920 1/20 0.31
ALOX5 P09917 1/20 0.31
IDH1 O75874 1/20 0.31
FFAR4 Q5NUL3 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Anpirtoline SCHEMBL3115824 0.98 MEN1 (0.97) MEN1KMT2ACYP1A2HTR3EHTR3B
SCHEMBL16334124 0.84 MEN1 (0.73) MEN1KMT2ACYP1A2HTR3EHTR3B
SCHEMBL16333873 0.84 MEN1 (0.73) MEN1KMT2ACYP1A2HTR3EHTR3B
SCHEMBL13039177 0.80 MEN1 (0.67) MEN1KMT2ACYP1A2SLC18A3SIGMAR1
SCHEMBL4675115 0.72 KMT2A (0.57) MEN1KMT2ACYP1A2ALDH1A1SLC18A3
SCHEMBL23166117 0.72 MEN1 (0.56) MEN1KMT2ACYP1A2HTR3EHTR3B
Hydrochloric Acid SCHEMBL4706173 0.71 KMT2A (0.55) MEN1KMT2ACYP1A2ALDH1A1SLC18A3
SCHEMBL30174508 0.70 MEN1 (0.54) MEN1KMT2ACYP1A2HTR3EHTR3B
SCHEMBL24338764 0.70 MEN1 (0.54) MEN1KMT2ACYP1A2HTR3EHTR3B
Hydrochloric Acid SCHEMBL20266524 0.69 MEN1 (0.53) MEN1KMT2ACYP1A2HTR3EHTR3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 220 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250295611-A1 METHODS OF TREATING 5HT2A RECEPTOR-MEDIATED CONDITIONS TESSELLATE THERAPEUTICS INC (US) 2025-09-25 US claimed
WO-2023212244-A1 METHODS OF TREATING 5HT2A RECEPTOR-MEDIATED CONDITIONS TESSELLATE THERAPEUTICS, INC. (US) 2023-11-02 WO claimed
US-20170112829-A1 USE OF COMPOUNDS BINDING TO THE SIGMA RECEPTOR LIGANDS FOR THE TREATMENT OF NEUROPATHIC PAIN DEVELOPING AS A CONSEQUENCE OF CHEMOTHERAPY LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2017-04-27 US claimed
US-20150320739-A1 Pharmaceutical Compositions for the Treatment of Sexual Disorders II BAUSCH HEALTH IRELAND LIMITED (F/K/A/ VALEANT PHARMACEUTICALS IRELAND LIMITED) (IE) 2015-11-12 US claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20130203766-A1 Pharmaceutical Compositions for the Treatment of Sexual Disorders II SPROUT PHARMACEUTICALS, INC. (US) 2013-08-08 US claimed
US-20130121923-A1 Treatment of Male Sexual Dysfunction PFIZER INC. (US) 2013-05-16 US claimed
US-20110105519-A1 Pharmaceutical Compositions for the Treatment of Sexual Disorders II SPROUT PHARMACEUTICALS, INC. 2011-05-05 US claimed
US-20110107442-A1 Treatment of Male Sexual Dysfunction IXCHELSIS LIMITED (GB) 2011-05-05 US claimed
US-20110052723-A1 USE OF COMPOUNDS BINDING TO THE SIGMA RECEPTOR LIGANDS FOR THE TREATMENT OF NEUROPATHIC PAIN DEVELOPING AS A CONSEQUENCE OF CHEMOTHERAPY LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2011-03-03 US claimed
EP-1470115-A1 TREATMENT OF MALE SEXUAL DYSFUNCTION Pfizer Limited (GB) 2004-10-27 EP claimed
US-20030229001-A1 Treatment of male sexual dysfunction PFIZER INC. 2003-12-11 US claimed
WO-2003064402-A1 TREATMENT OF MALE SEXUAL DYSFUNCTION PFIZER LIMITED (GB) 2003-08-07 WO claimed
US-20020173511-A1 Serotonergic compositions and methods for treatment of mild cognitive impairment WURTMAN RICHARD J (US) 2002-11-21 US claimed
CN-1355698-A Compound for medicine for treating function of bronchial contraction RESPIRATORIUS AB (SE) 2002-06-26 CN claimed
WO-2002038142-A2 SEROTONERGIC COMPOSITIONS AND METHODS FOR TREATMENT OF MILD COGNITIVE IMPAIRMENT MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2002-05-16 WO claimed
EP-1185263-A2 RECEPTOR AGONISTS AND ANTAGONISTS Respiratorius AB (SE) 2002-03-13 EP claimed
WO-2001015677-A2 USE OF 5-HT1B/1D AGONISTS TO TREAT OTIC PAIN ALCON LABORATORIES, INC. (US) 2001-03-08 WO claimed
WO-2000076500-A2 COMPOUND FOR USE AS A MEDICAMENT FOR TREATMENT OF DISORDERS INVOLVING BRONCHOCONTRACTION RESPIRATORIUS AB (SE) 2000-12-21 WO claimed
WO-1997044062-A1 THE USE OF 5-HT1B/1D AGONISTS TO TREAT OCULAR PAIN ALCON LABORATORIES, INC. (US) 1997-11-27 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130121923-A1 Treatment of Male Sexual Dysfunction OXTR, AVPR1B, AVPR2 MEN1 1452/4885KMT2A 4643/4885CYP1A2 2866/4885
US-20110107442-A1 Treatment of Male Sexual Dysfunction OXTR, AVPR1B, AVPR2 MEN1 1452/4885KMT2A 4643/4885CYP1A2 2866/4885
US-20250295611-A1 METHODS OF TREATING 5HT2A RECEPTOR-MEDIATED CONDITIONS HTR2A, HTR5A, HTR6 MEN1 2593/4885KMT2A 1760/4885CYP1A2 692/4885
US-20130203766-A1 Pharmaceutical Compositions for the Treatment of Sexual Disorders II FLNB, FLNA, FGB MEN1 2146/4885KMT2A 2027/4885CYP1A2 90/4885
US-20110105519-A1 Pharmaceutical Compositions for the Treatment of Sexual Disorders II FLNB, FLNA, FGB MEN1 2146/4885KMT2A 2027/4885CYP1A2 90/4885
US-20030229001-A1 Treatment of male sexual dysfunction OXTR, AVPR1B, AVPR2 MEN1 1452/4885KMT2A 4643/4885CYP1A2 2866/4885
US-20150320739-A1 Pharmaceutical Compositions for the Treatment of Sexual Disorders II FLNB, FLNA, FGB MEN1 2146/4885KMT2A 2027/4885CYP1A2 90/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.