Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 2/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | MLNR | O43193 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | GPR183 | P32249 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | CTSC | P53634 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4050438 | 0.84 | GPR119 (0.43) | TNFGPR119KCNH2JAK2JAK3 | |
| SCHEMBL17967843 | 0.84 | DRD2 (0.51) | GPR119KCNH2JAK2JAK3JAK1 | |
| Hydrochloric Acid SCHEMBL4055905 | 0.83 | GPR119 (0.43) | TNFGPR119KCNH2JAK2JAK3 | |
| SCHEMBL25364420 | 0.73 | GPR119 (0.40) | TNFGPR119STAT3GPR183ROCK2 | |
| SCHEMBL30541566 | 0.73 | GPR119 (0.40) | TNFGPR119STAT3GPR183ROCK2 | |
| SCHEMBL21770450 | 0.73 | PTGS2 (0.54) | KCNH2 | |
| SCHEMBL21769964 | 0.73 | RORC (0.46) | TNF | |
| SCHEMBL3981405 | 0.72 | KCNJ1 (0.47) | TNFGPR119KCNH2MLNRGPR183 | |
| SCHEMBL3051776 | 0.71 | HRH3 (0.48) | TNFMLNRHRH3 | |
| SCHEMBL14375228 | 0.71 | HRH3 (0.65) | GPR119KCNH2JAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2059516-A1 | PYRIDINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (publ) (SE) | 2009-05-20 | — | — | EP | claimed |
| WO-2008025798-A1 | PYRIDINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2008-03-06 | — | — | WO | claimed |