Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 2/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.37 |
| ▸ | FEN1 | P39748 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | GPR183 | P32249 | 1/20 | 0.36 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4055905 | 0.99 | GPR119 (0.43) | GPR119RORCTNFMERTKATR | |
| SCHEMBL3985271 | 0.84 | TNF (0.46) | GPR119TNFJAK2JAK1TYK2 | |
| SCHEMBL17967843 | 0.76 | DRD2 (0.51) | GPR119JAK2JAK1TYK2JAK3 | |
| SCHEMBL4060086 | 0.71 | RORC (0.46) | GPR119RORCTNFATR | |
| SCHEMBL4048443 | 0.70 | RORC (0.47) | GPR119RORCATRKCNH2 | |
| SCHEMBL4053994 | 0.70 | GPR119 (0.42) | GPR119RORCATRJAK3 | |
| SCHEMBL4387699 | 0.69 | HTR2A (0.41) | GPR119RORCATRJAK2KCNH2 | |
| SCHEMBL4048433 | 0.69 | RORC (0.41) | RORCATR | |
| SCHEMBL4053567 | 0.69 | GPR119 (0.47) | GPR119RORC | |
| SCHEMBL387443 | 0.68 | ALOX5AP (0.52) | RORCATRALOX5APFEN1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |