Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4742187 | 0.90 | USP1 (0.33) | USP1KDM4E | |
| SCHEMBL4913222 | 0.86 | PDPK1 (0.32) | — | |
| SCHEMBL4742985 | 0.83 | USP1 (0.36) | USP1 | |
| SCHEMBL4482238 | 0.83 | LYN (0.32) | — | |
| SCHEMBL4741763 | 0.81 | KDM4E (0.35) | USP1KDM4E | |
| SCHEMBL4743760 | 0.80 | USP1 (0.32) | USP1 | |
| SCHEMBL4490917 | 0.79 | BPTF (0.31) | KDM4E | |
| SCHEMBL4744316 | 0.75 | PDE2A (0.33) | USP1 | |
| SCHEMBL4489281 | 0.73 | KCNH2 (0.34) | USP1 | |
| SCHEMBL4485590 | 0.73 | TP53 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2034993-A2 | PYRAZINONES AS CELLULAR PROLIFERATION INHIBITORS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007149448-A2 | PYRAZINONES AS CELLULAR PROLIFERATION INHIBITORS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-12-27 | — | — | WO | disclosed |