Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 3/20 | 0.46 |
| ▸ | THRA | P10827 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.41 |
| ▸ | PPARD | Q03181 | 4/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3989733 | 0.89 | LMNA (0.39) | TDP1PTGDR2KDM4C | |
| SCHEMBL3980836 | 0.82 | PTGDR2 (0.51) | THRBTHRAPTGDR2KDM4C | |
| SCHEMBL3986238 | 0.79 | MAPKAPK2 (0.38) | THRBTHRAKDM4CMAPT | |
| SCHEMBL3777976 | 0.77 | TDP1 (0.44) | THRBTHRATDP1TSHRPTGDR2 | |
| SCHEMBL3984932 | 0.77 | TDP1 (0.46) | TDP1TSHRPTGDR2PPARGKDM4C | |
| SCHEMBL3983780 | 0.76 | THRB (0.46) | THRBTHRATDP1TSHRPTGDR2 | |
| SCHEMBL3776046 | 0.75 | TDP1 (0.46) | TDP1TSHRPTGDR2PPARDMAPT | |
| SCHEMBL3779168 | 0.74 | TDP1 (0.45) | THRBTHRATDP1TSHRPTGDR2 | |
| SCHEMBL3982787 | 0.73 | PTGDR2 (0.42) | PTGDR2PPARDPPARG | |
| SCHEMBL3782778 | 0.72 | PTGDR2 (0.46) | THRBTHRATDP1TSHRPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009060209-A1 | 6,6-FUSED BICYCLIC AROMATIC COMPOUNDS AND THEIR THERAPEUTI USE | ARGENTA DISCOVERY LIMITED (GB) | 2009-05-14 | — | — | WO | disclosed |
| WO-2009060209-A1 | 6,6-FUSED BICYCLIC AROMATIC COMPOUNDS AND THEIR THERAPEUTI USE | ARGENTA DISCOVERY LIMITED (GB) | 2009-05-14 | — | — | WO | disclosed |