Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 10/20 | 0.39 |
| ▸ | THRB | P10828 | 10/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3990206 | 0.90 | THRA (0.48) | THRATHRBPPARG | |
| SCHEMBL4528982 | 0.84 | THRA (0.49) | THRATHRBALOX5PPARGMTNR1A | |
| SCHEMBL4532920 | 0.84 | THRA (0.49) | THRATHRBALOX5PPARGMTNR1A | |
| SCHEMBL4522383 | 0.82 | THRB (0.52) | THRATHRBALOX5PPARG | |
| SCHEMBL3990040 | 0.78 | THRB (0.52) | THRATHRB | |
| SCHEMBL4518429 | 0.77 | ALOX5 (0.47) | THRATHRBALOX5PPARGMTNR1A | |
| SCHEMBL4527795 | 0.76 | THRB (0.52) | THRATHRBALOX5PPARGMTNR1A | |
| SCHEMBL3991551 | 0.75 | ALOX5 (0.49) | THRATHRBALOX5PPARGMTNR1A | |
| SCHEMBL4508675 | 0.75 | THRB (0.61) | THRATHRB | |
| SCHEMBL4518871 | 0.74 | THRA (0.48) | THRATHRBALOX5PPARGKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035377-A1 | INDOLE DERIVATIVES AND THEIR USE AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007134864-A1 | INDOLE DERIVATIVES AND THEIR USE AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2007-11-29 | — | — | WO | disclosed |