Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 17/20 | 0.52 |
| ▸ | THRA | P10827 | 16/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4508675 | 0.92 | THRB (0.61) | THRBTHRA | |
| SCHEMBL3990040 | 0.91 | THRB (0.52) | THRBTHRA | |
| SCHEMBL4532920 | 0.90 | THRA (0.49) | THRBTHRAPPARGALOX5AKR1C2 | |
| SCHEMBL3990206 | 0.90 | THRA (0.48) | THRBTHRAPPARG | |
| SCHEMBL3995101 | 0.84 | THRB (0.56) | THRBTHRAAKR1C2 | |
| SCHEMBL4527795 | 0.82 | THRB (0.52) | THRBTHRAPPARGALOX5 | |
| SCHEMBL3990201 | 0.82 | THRA (0.39) | THRBTHRAPPARGALOX5 | |
| SCHEMBL4518429 | 0.80 | ALOX5 (0.47) | THRBTHRAPPARGALOX5AKR1C2 | |
| SCHEMBL4528982 | 0.78 | THRA (0.49) | THRBTHRAPPARGALOX5AKR1C2 | |
| SCHEMBL3990450 | 0.78 | THRB (0.54) | THRBTHRAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080835-A1 | THYROMIMETRIC COMPOUNDS IN TREATMENT OF DISEASE RELATED TO SONIC HEDGEHOG SIGNALLING | KARO BIO AB (SE) | 2009-07-02 | — | — | WO | claimed |
| US-20090233979-A1 | Indole Derivatives and Their Use as Thyroid Receptor Ligands | KARO BIO AB (SE) | 2009-09-17 | — | — | US | disclosed |
| WO-2009080835-A1 | THYROMIMETRIC COMPOUNDS IN TREATMENT OF DISEASE RELATED TO SONIC HEDGEHOG SIGNALLING | KARO BIO AB (SE) | 2009-07-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233979-A1 | Indole Derivatives and Their Use as Thyroid Receptor Ligands | TSHR, TRHR, THRA | THRB 4/4885THRA 3/4885PPARG 195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.