Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | TACR1 | P25103 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8563554 | 0.81 | BCHE (0.57) | BCHECYP2D6KDM4ELMNAHTT | |
| SCHEMBL2754242 | 0.80 | RAB9A (0.70) | BCHECYP2D6KDM4ELMNAHTT | |
| SCHEMBL1856027 | 0.77 | BCHE (0.79) | BCHECYP2D6KDM4ELMNAHTT | |
| SCHEMBL1520405 | 0.76 | BCHE (0.57) | BCHECYP2D6KDM4ELMNAHTT | |
| SCHEMBL514643 | 0.73 | SIRT2 (0.42) | — | |
| SCHEMBL1553262 | 0.72 | L3MBTL1 (0.54) | CYP2D6LMNAJAK2KMT2ADRD3 | |
| SCHEMBL3120511 | 0.72 | BCHE (0.52) | BCHECYP2D6KDM4ELMNAHTT | |
| SCHEMBL24975491 | 0.71 | NCF1 (0.54) | CYP2D6KDM4ELMNAHTTMAPK1 | |
| SCHEMBL31428486 | 0.71 | NCF1 (0.54) | CYP2D6KDM4ELMNAHTTMAPK1 | |
| SCHEMBL30492135 | 0.70 | HTR6 (0.51) | BCHECYP2D6KDM4ELMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035436-A1 | FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma S.A. (BE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2008001076-A1 | FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2008-01-03 | — | — | WO | disclosed |