SCHEMBL8563554

SCHEMBL8563554

O=C1OCCN1Cc1c[nH]c2ccccc12

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCHE P06276 1/20 0.57
CYP2D6 P10635 1/20 0.57
NAAA Q02083 1/20 0.56
KDM4E B2RXH2 2/20 0.54
LMNA P02545 2/20 0.54
HTT P42858 1/20 0.54
MAPK1 P28482 1/20 0.54
TACR1 P25103 1/20 0.53
RAB9A P51151 2/20 0.52
JAK2 O60674 1/20 0.52
HTR6 P50406 1/20 0.51
MAPT P10636 2/20 0.49
KMT2A Q03164 2/20 0.49
NPSR1 Q6W5P4 1/20 0.49
DRD2 P14416 4/20 0.49
DRD4 P21917 3/20 0.49
DRD3 P35462 3/20 0.49
L3MBTL1 Q9Y468 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
HCRTR2 O43614 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1520405 0.83 BCHE (0.57) BCHECYP2D6KDM4ELMNAHTT
SCHEMBL3996399 0.81 BCHE (0.55) BCHECYP2D6KDM4ELMNAHTT
SCHEMBL20695806 0.78 KDM4E (0.44) CYP2D6NAAAKDM4ERAB9AMAPT
SCHEMBL2754242 0.76 RAB9A (0.70) BCHECYP2D6KDM4ELMNAHTT
SCHEMBL5584770 0.75 MPO (0.51) CYP2D6KDM4ETACR1RAB9AMAPT
SCHEMBL7855620 0.74 POLB (0.55) BCHENAAAKDM4EMAPK1TACR1
SCHEMBL1856027 0.74 BCHE (0.79) BCHECYP2D6KDM4ELMNAHTT
SCHEMBL19612754 0.72 NAAA (1.00) NAAAMAPT
SCHEMBL3120511 0.71 BCHE (0.52) BCHECYP2D6KDM4ELMNAHTT
SCHEMBL1849016 0.71 LMNA (0.90) BCHECYP2D6KDM4ELMNAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0665846-B1 TOPOISOMERASE II INHIBITORS AND THERAPEUTIC USES THEREFOR US HEALTH (US) 1998-07-29 EP disclosed
US-5747520-A AZATOXIN DERIVATIVES; ANTITUMOR AND ANTICARCINOGENIC AGENTS US ARMY (US) 1998-05-05 US disclosed
US-5606060-A ANTITUMOR AGENTS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH & HUMAN SERVICES (US) 1997-02-25 US disclosed
EP-0665846-A1 TOPOISOMERASE II INHIBITORS AND THERAPEUTIC USES THEREFOR THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1995-08-09 EP disclosed
WO-1994010175-A1 TOPOISOMERASE II INHIBITORS AND THERAPEUTIC USES THEREFOR THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES (US) 1994-05-11 WO disclosed