Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.52 |
| ▸ | KMO | O15229 | 1/20 | 0.51 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1271891 | 0.86 | KMO (0.61) | POLBHTTLMNAHSD17B10GPR55 | |
| SCHEMBL3113600 | 0.84 | KMT2A (0.60) | POLBHTTLMNAHSD17B10GPR55 | |
| SCHEMBL13848187 | 0.84 | PIK3CA (0.56) | POLBHTTLMNAHSD17B10GPR55 | |
| SCHEMBL2815977 | 0.82 | KMT2A (0.55) | POLBHTTLMNAPIK3CAPIK3R1 | |
| SCHEMBL3997688 | 0.82 | ALDH1A1 (0.51) | POLBHTTLMNAHSD17B10GPR55 | |
| SCHEMBL3114998 | 0.81 | KMO (0.56) | POLBHTTLMNAHSD17B10GPR55 | |
| SCHEMBL5528147 | 0.81 | PIK3CA (0.47) | POLBHTTLMNAHSD17B10GPR55 | |
| SCHEMBL3113677 | 0.81 | LMNA (0.51) | POLBHTTLMNAHSD17B10GPR55 | |
| SCHEMBL10266109 | 0.81 | KDM4E (0.49) | POLBHTTLMNAHSD17B10GPR55 | |
| SCHEMBL27681005 | 0.81 | ALDH1A1 (0.63) | POLBHTTLMNAHSD17B10GPR55 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009066084-A1 | 2 -MORPHOLINOPYRIMIDINES AND THEIR USE AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-05-28 | — | — | WO | disclosed |