SCHEMBL1271891

SCHEMBL1271891

O=C(O)c1cc(N2CCOCC2)nc(N2CCOCC2)n1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMO O15229 1/20 0.61
▸ KMT2A Q03164 2/20 0.58
▸ KDM4E B2RXH2 3/20 0.54
▸ ALDH1A1 P00352 3/20 0.54
▸ MEN1 O00255 1/20 0.54
▸ GAA P10253 1/20 0.54
▸ THRB P10828 1/20 0.54
▸ SMN1; SMN2 Q16637 1/20 0.54
▸ NPSR1 Q6W5P4 1/20 0.51
▸ HRH4 Q9H3N8 1/20 0.51
▸ POLB P06746 2/20 0.51
▸ HTT P42858 2/20 0.51
▸ PKM P14618 1/20 0.51
▸ LMNA P02545 1/20 0.51
▸ HSD17B10 Q99714 1/20 0.51
▸ GPR55 Q9Y2T6 1/20 0.51
▸ PIK3CA P42336 6/20 0.51
▸ MTOR P42345 1/20 0.50
▸ PIK3R1 P27986 1/20 0.48
▸ MAP3K12 Q12852 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3114998 0.94 KMO (0.56) KMOKMT2AKDM4EALDH1A1MEN1
SCHEMBL3118342 0.91 KMO (0.52) KMOKMT2AKDM4EALDH1A1MEN1
SCHEMBL3105290 0.89 KMT2A (0.51) KMOKMT2AKDM4EALDH1A1MEN1
SCHEMBL3113412 0.88 KMO (0.50) KMOKMT2AKDM4EALDH1A1MEN1
SCHEMBL3114736 0.87 KMO (0.49) KMOKMT2AKDM4EALDH1A1MEN1
SCHEMBL3100732 0.87 KMO (0.49) KMOKMT2AKDM4EALDH1A1MEN1
SCHEMBL3107368 0.86 HSD17B10 (0.57) KMOKDM4EALDH1A1SMN1; SMN2POLB
SCHEMBL6651425 0.86 POLB (0.64) KMOKMT2AKDM4EALDH1A1MEN1
SCHEMBL3997510 0.86 POLB (0.52) KMOKMT2AKDM4EALDH1A1MEN1
SCHEMBL3116377 0.86 PIK3CA (0.50) KMOKMT2AKDM4EALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2200440-B1 ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS CRESTONE INC (US) 2017-07-19 — — EP claimed
US-8236795-B2 IL-12 modulatory compounds SYNTA PHARMACEUTICALS CORP. (US) 2012-08-07 — — US claimed
US-20100256132-A1 IL-12 MODULATORY COMPOUNDS SYNTA PHARMACEUTICALS CORPORATION (US) 2010-10-07 — — US claimed
EP-2200440-A1 ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS Crestone, Inc. (US) 2010-06-30 — — EP claimed
US-7696202-B2 IL-12 modulatory compounds SYNTA PHARMACEUTICALS CORP. (US) 2010-04-13 — — US claimed
WO-2009015208-A1 ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS REPLIDYNE, INC. (US) 2009-01-29 — — WO claimed
EP-1819341-A2 IL-12 MODULATORY COMPOUNDS Synta Pharmaceuticals Corporation (US) 2007-08-22 — — EP claimed
US-20060223996-A1 IL-12 modulatory compounds SYNTA PHARMACEUTICALS CORP. (US) 2006-10-05 — — US claimed
WO-2006053227-A2 IL-12 MODULATORY COMPOUNDS SYNTA PHARMACEUTICALS CORP. (US) 2006-05-18 — — WO claimed
EP-4684011-A1 METHOD FOR ISOLATING NUCLEIC ACID FROM A BIOLOGICAL SAMPLE Bioecho Life Sciences GmbH (DE) 2026-01-28 — — EP disclosed
US-20250277207-A1 One or Multiple-Steps Extraction of Nucleic Acids and other Biomolecules using a Cloudy Precipitated Solution CHHALLIYIL PRADHEEP (US) 2025-09-04 — — US disclosed
WO-2024194332-A1 METHOD FOR ISOLATING NUCLEIC ACID FROM A BIOLOGICAL SAMPLE BIOECHO LIFE SCIENCES GMBH (DE) 2024-09-26 — — WO disclosed
US-11957757-B2 Method for preparing stabilized metal ion ligand nanocomplex and compositions thereof AUBURN UNIVERSITY (US) 2024-04-16 — — US disclosed
US-20230303995-A1 ISOLATION OF NUCLEIC ACIDS AT ELEVATED TEMPERATURES BIOECHO LIFE SCIENCES GMBH (DE) 2023-09-28 — — US disclosed
WO-2006053227-A2 IL-12 MODULATORY COMPOUNDS SYNTA PHARMACEUTICALS CORP. (US) 2006-05-18 — — WO disclosed
US-20060063782-A1 3-Hetero arylmethoxy ! pyridines and their analogues as p38 map kinase inhibitors ASTEX THERAPEUTICS LIMITED (GB) 2006-03-23 — — US disclosed
EP-1545523-A1 3-&-grave;(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES ASP38 MAP KINASE INHIBITORS Astex Technology Limited (GB) 2005-06-29 — — EP disclosed
WO-2005002673-A1 RAF KINASE INHIBITORS ASTEX THERAPEUTICS LIMITED (GB) 2005-01-13 — — WO disclosed
US-6759412-B2 FOR PRODUCING DRUGS USED FOR THERAPY OF CARDIOVASCULAR DISEASES, STABLE OR UNSTABLE ANGINA PECTORIS, CORONARY HEART DISEASE, PRINZMETAL ANGINA, ACUTE CORONARY SYNDROME, HEART FAILURE, MYOCARDIAL INFARCTION, STROKE, THROMBOSIS AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2004-07-06 — — US disclosed
WO-2004004720-A1 3-`(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES AS P38 MAP KINASE INHIBITORS ASTEX TECHNOLOGY LIMITED (GB) 2004-01-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060223996-A1 IL-12 modulatory compounds IL2, IL4, IFNG KMO 1707/4885KMT2A 3672/4885KDM4E 3666/4885
US-20060063782-A1 3-Hetero arylmethoxy ! pyridines and their analogues as p38 map kinase inhibitors MAPK1, MAPK3, MAPK10 KMO 860/4885KMT2A 2277/4885KDM4E 3553/4885
US-11957757-B2 Method for preparing stabilized metal ion ligand nanocomplex and compositions thereof NSFL1C, SOD1, CLTC KMO 4171/4885KMT2A 2229/4885KDM4E 4603/4885
US-20100256132-A1 IL-12 MODULATORY COMPOUNDS IL2, IL4, IFNG KMO 1707/4885KMT2A 3672/4885KDM4E 3666/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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