Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | PKM | P14618 | 1/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 1.00 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.41 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.41 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.41 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.41 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.41 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10683199 | 0.98 | MAPT (0.95) | MAPTKDM4EALDH1A1MEN1GAA | |
| SCHEMBL1646406 | 0.95 | ALDH1A1 (0.91) | MAPTKDM4EALDH1A1MEN1GAA | |
| SCHEMBL21155841 | 0.84 | ALDH1A1 (0.72) | MAPTKDM4EALDH1A1MEN1GAA | |
| SCHEMBL6568351 | 0.81 | MAPT (0.67) | MAPTKDM4EALDH1A1MEN1GAA | |
| SCHEMBL11347157 | 0.81 | MEN1 (0.67) | MAPTKDM4EALDH1A1MEN1GAA | |
| SCHEMBL1535914 | 0.75 | MAPT (0.59) | MAPTKDM4EALDH1A1MEN1GAA | |
| SCHEMBL5837186 | 0.75 | KMT2A (0.59) | MAPTKDM4EALDH1A1MEN1GAA | |
| SCHEMBL12023176 | 0.74 | ALDH1A1 (0.58) | MAPTKDM4EALDH1A1MEN1GAA | |
| SCHEMBL18830558 | 0.73 | MEN1 (0.57) | MAPTKDM4EALDH1A1MEN1GAA | |
| SCHEMBL24869713 | 0.72 | DRD1 (0.69) | MAPTKDM4EALDH1A1MEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040261198-A1 | Restructuring and finishing of keratin fibers | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) | 2004-12-30 | — | — | US | claimed |
| EP-1455736-A1 | RESTRUCTURING AND FINISHING OF KERATIN FIBERS | Henkel Kommanditgesellschaft auf Aktien (DE) | 2004-09-15 | — | — | EP | claimed |
| WO-2003053375-A1 | RESTRUCTURING AND FINISHING OF KERATIN FIBERS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2003-07-03 | — | — | WO | claimed |
| US-4620010-A | Process for preparing carboalkoxy substituted benzoxazole compounds | USV PHARMACEUTICAL CORP. (US) | 1986-10-28 | — | — | US | claimed |
| EP-3705477-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2020-09-09 | — | — | EP | disclosed |
| US-10662192-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-05-26 | — | — | US | disclosed |
| EP-3216787-B1 | INTERMEDIATES FOR THE PREPARATION OF MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMA (US) | 2020-02-19 | — | — | EP | disclosed |
| US-20190144450-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-05-16 | — | — | US | disclosed |
| EP-3216787-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2017-09-13 | — | — | EP | disclosed |
| EP-2502911-B1 | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2017-04-05 | — | — | EP | disclosed |
| US-20160318931-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-11-03 | — | — | US | disclosed |
| US-20150315186-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED | 2015-11-05 | — | — | US | disclosed |
| EP-0894796-A1 | Imidazolines substituted with a heterocyclic ring as alpha-2 antagonists | ADIR ET COMPAGNIE (FR) | 1999-02-03 | — | — | EP | disclosed |
| EP-0070531-B1 | TETRAHYDRONAPHTHOXAZOLES | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1988-03-02 | — | — | EP | disclosed |
| US-4620010-A | Process for preparing carboalkoxy substituted benzoxazole compounds | USV PHARMACEUTICAL CORP. (US) | 1986-10-28 | — | — | US | disclosed |
| US-4443610-A | Bicyclothiazoles | USV PHARMACEUTICAL CORPORATION (US) | 1984-04-17 | — | — | US | disclosed |
| US-4440935-A | Bicycloimidazoles | USV PHARMACEUTICAL CORPORATION (US) | 1984-04-03 | — | — | US | disclosed |
| EP-0070531-A2 | Tetrahydronaphthoxazoles | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1983-01-26 | — | — | EP | disclosed |
| US-4368201-A | Tetrahydronaphthoxazoles | USV PHARMACEUTICAL CORPORATION (US) | 1983-01-11 | — | — | US | disclosed |
| US-4110246-A | OPTICAL BRIGHTENERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190144450-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | MAPT 4269/4885KDM4E 4262/4885ALDH1A1 2165/4885 |
| US-10662192-B2 | Modulators of ATP-binding cassette transporters | CFTR, ABCB1, ABCC2 | MAPT 4269/4885KDM4E 4262/4885ALDH1A1 2165/4885 |
| US-20150315186-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | MAPT 4269/4885KDM4E 4262/4885ALDH1A1 2165/4885 |
| US-20160318931-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | MAPT 4269/4885KDM4E 4262/4885ALDH1A1 2165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.