Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LGMN | Q99538 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7941017 | 0.87 | MAPK1 (0.47) | MAPTPOLBLGMNRAB9AMAPK1 | |
| SCHEMBL7939410 | 0.80 | ALDH1A1 (0.38) | MAPTPOLBRAB9AMAPK1ALDH1A1 | |
| SCHEMBL7944340 | 0.80 | MAPT (0.36) | MAPTPOLBALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL3234865 | 0.79 | GUCY1B2 (0.44) | — | |
| SCHEMBL7937211 | 0.79 | GUCY1B2 (0.43) | MAPTRAB9AMAPK1ALDH1A1NPC1 | |
| SCHEMBL4000642 | 0.79 | GUCY1B2 (0.45) | — | |
| SCHEMBL7940148 | 0.77 | CD274 (0.35) | SMN1; SMN2 | |
| SCHEMBL3229753 | 0.72 | GUCY1B2 (0.47) | — | |
| SCHEMBL4000871 | 0.72 | L3MBTL1 (0.38) | ALDH1A1 | |
| SCHEMBL3998970 | 0.72 | GUCY1B2 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015652-A2 | THIAZOLE COMPOUNDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |