Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL109203 | 0.74 | SIRT6 (0.41) | RAB9ANPC1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL109899 | 0.73 | SMYD3 (0.40) | RAB9ANPC1PKMSMN1; SMN2TP53 | |
| SCHEMBL106823 | 0.72 | RAB9A (0.49) | RAB9ANPC1MAPTPKMGLA | |
| SCHEMBL2781825 | 0.72 | KMT2A (0.40) | HDAC1HDAC6 | |
| SCHEMBL106400 | 0.72 | PSMB8 (0.40) | RAB9ANPC1HPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL107632 | 0.70 | CTSA (0.46) | RAB9ANPC1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL106421 | 0.69 | CTSA (0.47) | CNR2 | |
| SCHEMBL4002227 | 0.69 | ROCK1 (0.51) | RAB9ANPC1SMN1; SMN2HDAC1HDAC6 | |
| Water SCHEMBL11526103 | 0.66 | CA12 (0.35) | — | |
| SCHEMBL11591493 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424869-A1 | 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | Glaxo Group Limited (GB) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010125102-A1 | 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-11-04 | — | — | WO | disclosed |