Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 4/20 | 0.45 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL231675 | 0.91 | ALDH1A1 (0.48) | ACHEALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL485968 | 0.89 | ALDH1A1 (0.50) | ACHEALDH1A1HPGDNPC1RAB9A | |
| Bromide SCHEMBL231806 | 0.85 | DNM1 (0.43) | ACHEALDH1A1HPGDNPC1RAB9A | |
| Bromide SCHEMBL232863 | 0.85 | DNM1 (0.43) | ACHEALDH1A1HPGDNPC1RAB9A | |
| Bromide SCHEMBL4775467 | 0.84 | ACHE (0.53) | ACHEBCHEHPGDNPC1RAB9A | |
| SCHEMBL321584 | 0.84 | ALDH1A1 (0.44) | ACHEALDH1A1HPGDNPC1RAB9A | |
| Bromide SCHEMBL231434 | 0.84 | DNM1 (0.59) | ACHEALDH1A1HPGDNPC1RAB9A | |
| Bromide SCHEMBL29669478 | 0.84 | DNM1 (0.51) | ACHEALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL487054 | 0.84 | ALDH1A1 (0.44) | ACHEALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL5051511 | 0.83 | ACHE (0.56) | ACHEBCHEHPGDNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2068828-A2 | BIODEGRADABLE OCULAR IMPLANTS AND METHODS FOR TREATING OCULAR CONDITIONS | SurModics, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1937327-A1 | NATURAL BIODEGRADABLE MATRICES AND USES THEREOF | SurModics, Inc. (US) | 2008-07-02 | — | — | EP | disclosed |
| EP-1926504-A1 | COATINGS AND ARTICLES INCLUDING NATURAL BIODEGRADABLE POLYSACCHARIDES | SurModics, Inc. (US) | 2008-06-04 | — | — | EP | disclosed |
| WO-2008060359-A2 | BIODEGRADABLE OCULAR IMPLANTS AND METHODS FOR TREATING OCULAR CONDITIONS | SURMODICS, INC. (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2007035886-A1 | NATURAL BIODEGRADABLE MATRICES AND USES THEREOF | SURMODICS, INC. (US) | 2007-03-29 | — | — | WO | disclosed |
| WO-2007035865-A1 | COATINGS AND ARTICLES INCLUDING NATURAL BIODEGRADABLE POLYSACCHARIDES | SURMODICS, INC. (US) | 2007-03-29 | — | — | WO | disclosed |