Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4434712 | 0.78 | CA1 (0.46) | CA1CA2POLBKMT2AALDH1A1 | |
| SCHEMBL4601476 | 0.75 | CA1 (0.42) | CA1CA2POLBKMT2AALDH1A1 | |
| SCHEMBL27924346 | 0.69 | CA1 (0.37) | CA1CA2POLBKMT2AALDH1A1 | |
| SCHEMBL20599612 | 0.68 | ALDH1A1 (0.42) | CA1CA2POLBKMT2AALDH1A1 | |
| SCHEMBL27550826 | 0.68 | CA1 (0.55) | CA1CA2POLBKMT2AALDH1A1 | |
| SCHEMBL1820165 | 0.67 | L3MBTL1 (0.34) | POLBALDH1A1 | |
| SCHEMBL13713463 | 0.65 | POLB (0.51) | POLBKMT2AALDH1A1 | |
| SCHEMBL89736 | 0.65 | — | — | |
| SCHEMBL20599628 | 0.64 | SMN1; SMN2 (0.41) | POLBKMT2AALDH1A1MEN1TSHR | |
| Cyclopropane SCHEMBL9640900 | 0.64 | GLRA1 (0.37) | ALDH1A1TSHRUSP2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1684759-A4 | 4-PHENYL PIPERDINE SULFONYL GLYCINE TRANSPORTER INHIBITORS | MERCK & CO INC (US) | 2009-06-10 | — | — | EP | disclosed |
| EP-1684759-A2 | 4-PHENYL PIPERDINE SULFONYL GLYCINE TRANSPORTER INHIBITORS | Merck & Co., Inc. (US) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005046601-A3 | 4-PHENYL PIPERDINE SULFONYL GLYCINE TRANSPORTER INHIBITORS | MERCK & CO INC (US) | 2005-08-18 | — | — | WO | disclosed |
| WO-2005046601-A2 | 4-PHENYL PIPERDINE SULFONYL GLYCINE TRANSPORTER INHIBITORS | MERCK & CO., INC. (US) | 2005-05-26 | — | — | WO | disclosed |