Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 known ✓ | P45452 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | NAAA | Q02083 | 2/20 | 0.40 |
| ▸ | CTRC | Q99895 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ACER2 | Q5QJU3 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9458857 | 1.00 | NR1I2 (0.47) | NR1I2NAAACTRCHTR2AASAH1 | |
| Potassium Ion SCHEMBL10982840 | 0.97 | NR1I2 (0.47) | NR1I2NAAACTRCHTR2AASAH1 | |
| SCHEMBL4773215 | 0.97 | NR1I2 (0.50) | NR1I2NAAACTRCHTR2AASAH1 | |
| SCHEMBL11091808 | 0.97 | NR1I2 (0.50) | NR1I2NAAACTRCHTR2AASAH1 | |
| SCHEMBL8014431 | 0.97 | NR1I2 (0.47) | NR1I2NAAACTRCHTR2AASAH1 | |
| SCHEMBL11518709 | 0.97 | NR1I2 (0.50) | NR1I2NAAACTRCHTR2AASAH1 | |
| SCHEMBL8030244 | 0.97 | NR1I2 (0.47) | NR1I2NAAACTRCHTR2AASAH1 | |
| SCHEMBL8024763 | 0.97 | NR1I2 (0.47) | NR1I2NAAACTRCHTR2AASAH1 | |
| SCHEMBL11519233 | 0.97 | NR1I2 (0.50) | NR1I2NAAACTRCHTR2AASAH1 | |
| SCHEMBL194471 | 0.97 | NR1I2 (0.50) | NR1I2NAAACTRCHTR2AASAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1609362-B1 | Non-systemic control of parasites | BAYER IP GMBH (DE) | 2015-03-18 | — | — | EP | disclosed |
| US-8728507-B2 | Non-systemic control of parasites | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-05-20 | — | — | US | disclosed |
| US-7517535-B2 | Non-systemic control of parasites | BAYER ANIMAL HEALTH GMBH (DE) | 2009-04-14 | — | — | US | disclosed |
| US-20080108670-A1 | NON-SYSTEMIC CONTROL OF PARASITES | BAYER HEALTHCARE AG (DE) | 2008-05-08 | — | — | US | disclosed |
| US-20080108671-A1 | NON-SYSTEMIC CONTROL OF PARASITES | BAYER HEALTHCARE AG (DE) | 2008-05-08 | — | — | US | disclosed |
| EP-0764022-B1 | AGONISTS AND ANTAGONISTS OF THE NICOTINIC ACETYLCHOLINE RECEPTORS OF INSECTS TO CONTROL ENDOPARASITES | BAYER HEALTHCARE AG (DE) | 2006-12-20 | — | — | EP | disclosed |
| US-20060276517-A1 | Non-systemic control of parasites | BAYER HEALTHCARE AG (DE) | 2006-12-07 | — | — | US | disclosed |
| EP-1609362-A2 | Non-systemic control of parasites | Bayer HealthCare AG (DE) | 2005-12-28 | — | — | EP | disclosed |
| EP-0682869-B1 | Non-systemic control of parasites | BAYER HEALTHCARE AG (DE) | 2005-12-21 | — | — | EP | disclosed |
| US-20050266996-A1 | Combinations of crop protection agents with organic or inorganic carrier materials | BAYER CROPSCIENCE GMBH (DE) | 2005-12-01 | — | — | US | disclosed |
| US-20020042345-A1 | Combination of crop protection agents with hydrogen bond-forming polymers | AVENTIS CROPSCIENCE GMBH (DE) | 2002-04-11 | — | — | US | disclosed |
| US-20020019314-A1 | Combinations of crop protection agents with cationic polymers | AVENTIS CROPSCIENCE GMBH (DE) | 2002-02-14 | — | — | US | disclosed |
| US-20020010099-A1 | Combinations of crop protection agents with anionic polymers | AVENTIS CROPSCIENCE GMBH (DE) | 2002-01-24 | — | — | US | disclosed |
| US-6329374-B1 | CONTROLLING PARASITES SUCH AS LICE AND FLEAS | BAYER AKTIENGESELLSCHAFT (DE) | 2001-12-11 | — | — | US | disclosed |
| US-20010044456-A1 | Antagonists/agonists of nicotinergic acetylcholine receptors in insects; imidacloprid; such as fleas, lice and flies | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2001-11-22 | — | — | US | disclosed |
| US-20010021716-A1 | Non-systemic control of parasites | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2001-09-13 | — | — | US | disclosed |
| US-6232328-B1 | CONTACTING FLEAS AND LIC ON A HUMAN OR ANIMALS WITH AN IMIDAZOLINIUM COMPOUND TO KILL FLIES AND INSECTS | BAYER AKTIENGESELLSCHAFT (DE) | 2001-05-15 | — | — | US | disclosed |
| EP-0764022-A1 | AGONISTS AND ANTAGONISTS OF THE NICOTINIC ACETYLCHOLINE RECEPTORS OF INSECTS TO CONTROL ENDOPARASITES | BAYER AG (DE) | 1997-03-26 | — | — | EP | disclosed |
| WO-1995033453-A1 | AGONISTS AND ANTAGONISTS OF THE NICOTINIC ACETYLCHOLINE RECEPTORS OF INSECTS TO CONTROL ENDOPARASITES | BAYER AKTIENGESELLSCHAFT (DE) | 1995-12-14 | — | — | WO | disclosed |
| EP-0682869-A1 | Non-systemic control of parasites | BAYER AG (DE) | 1995-11-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276517-A1 | Non-systemic control of parasites | CHRNG, CHRNA1, CHRM3 | MMP13 3383/4885NR1I2 2021/4885NAAA 322/4885 |
| US-20020019314-A1 | Combinations of crop protection agents with cationic polymers | PEF1, CTSA, PARG | MMP13 3694/4885NR1I2 4530/4885NAAA 101/4885 |
| US-20020042345-A1 | Combination of crop protection agents with hydrogen bond-forming polymers | CAT, GPX4, GPX1 | MMP13 1407/4885NR1I2 4631/4885NAAA 138/4885 |
| US-20080108671-A1 | NON-SYSTEMIC CONTROL OF PARASITES | CHRNG, CHRNA1, CHRM3 | MMP13 3383/4885NR1I2 2021/4885NAAA 322/4885 |
| US-20010021716-A1 | Non-systemic control of parasites | CHRNG, CHRNA1, CHRM3 | MMP13 3383/4885NR1I2 2021/4885NAAA 322/4885 |
| US-20080108670-A1 | NON-SYSTEMIC CONTROL OF PARASITES | CHRNG, CHRNA1, CHRM3 | MMP13 3383/4885NR1I2 2021/4885NAAA 322/4885 |
| US-20010044456-A1 | Antagonists/agonists of nicotinergic acetylcholine receptors in insects; imidacloprid; such as fleas, lice and flies | CHRNG, CHRNE, CHRNA1 | MMP13 3831/4885NR1I2 1003/4885NAAA 285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.