Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CCR4 | P51679 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13769538 | 0.92 | MAPT (0.38) | MAPTKDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL4014280 | 0.84 | EGLN1 (0.34) | MAPTKDM4ENPSR1TP53POLB | |
| SCHEMBL13769676 | 0.82 | MAPT (0.39) | MAPTKDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL4007097 | 0.80 | ALOX15 (0.36) | MAPTKDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL4007615 | 0.80 | SRC (0.43) | MAPTPOLBSRCMEN1KMT2A | |
| SCHEMBL4008754 | 0.79 | FLT4 (0.44) | MAPTALDH1A1HPGDPOLBSRC | |
| SCHEMBL13769532 | 0.79 | PDE4B (0.41) | MAPTKDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL13769671 | 0.77 | SRC (0.45) | MAPTKDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL4006132 | 0.77 | P2RX7 (0.43) | MAPTKDM4EALDH1A1POLBSRC | |
| SCHEMBL13769525 | 0.77 | MAPT (0.40) | MAPTKDM4EALDH1A1HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080682-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |