Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CCR4 | P51679 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | ADK | P55263 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4013000 | 0.91 | CCR4 (0.39) | POLBCCR4PTGDR2MCL1P2RX7 | |
| SCHEMBL13769676 | 0.86 | MAPT (0.39) | KDM4ENPSR1MAPTSRCTP53 | |
| SCHEMBL4007615 | 0.86 | SRC (0.43) | EGLN1POLBMAPTCCR4SRC | |
| SCHEMBL4006629 | 0.84 | MAPT (0.38) | KDM4ENPSR1POLBMAPTCCR4 | |
| SCHEMBL4007097 | 0.84 | ALOX15 (0.36) | EGLN1KDM4ENPSR1POLBMAPT | |
| SCHEMBL4008754 | 0.83 | FLT4 (0.44) | EGLN1POLBMAPTCCR4SRC | |
| SCHEMBL4006132 | 0.83 | P2RX7 (0.43) | EGLN1KDM4EPOLBMAPTSRC | |
| SCHEMBL13769690 | 0.81 | STAT3 (0.38) | EGLN1POLBMAPTSRCPTGDR2 | |
| SCHEMBL4005788 | 0.80 | MAPT (0.43) | KDM4EMAPTADKTP53 | |
| SCHEMBL4006053 | 0.79 | LMNA (0.47) | KDM4ENPSR1POLBMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080682-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |