Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 14/20 | 0.49 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 2/20 | 0.37 |
| ▸ | CLK2 | P49760 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4009389 | 0.77 | CDC7 (0.44) | TRPA1TRPM8CDC7CLK2GSK3B | |
| SCHEMBL4008243 | 0.74 | ITK (0.48) | TRPA1CLK2DYRK1ACLK3FGFR1 | |
| SCHEMBL4008937 | 0.73 | TRPA1 (0.48) | TRPA1TRPM8CDC7CLK2GSK3B | |
| SCHEMBL4008236 | 0.68 | NR3C1 (0.38) | TRPA1 | |
| SCHEMBL4009386 | 0.62 | ITK (0.56) | CLK2DYRK1ACLK3FGFR1CDK2 | |
| SCHEMBL9818427 | 0.62 | KDR (0.54) | — | |
| SCHEMBL23783032 | 0.62 | TRPA1 (0.59) | TRPA1TRPM8CLK2GSK3BCDK5 | |
| SCHEMBL20267944 | 0.61 | TRPA1 (1.00) | TRPA1TRPM8 | |
| Indazole SCHEMBL4583780 | 0.61 | HSP90AA1 (0.76) | CLK2GSK3BCDK5DYRK1ACLK4 | |
| SCHEMBL702063 | 0.61 | RAB9A (0.65) | TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7473701-B2 | Substituted indazoles, compositions containing them, method of production and use | AVENTIS PHARMA S.A. (FR) | 2009-01-06 | — | — | US | claimed |