Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 8/20 | 0.53 |
| ▸ | NR1H3 | Q13133 | 8/20 | 0.53 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4014540 | 0.87 | NR1H2 (0.48) | NR1H2NR1H3PTGDR2RXRAPIK3CD | |
| SCHEMBL4009254 | 0.86 | NR1H2 (0.47) | NR1H2NR1H3PTGDR2RXRAPIK3CD | |
| SCHEMBL4012417 | 0.82 | NR1H2 (0.51) | NR1H2NR1H3PTGDR2RXRANCF1 | |
| SCHEMBL1125582 | 0.81 | NR1H2 (0.62) | NR1H2NR1H3PTGDR2RXRAPIK3CD | |
| SCHEMBL2446200 | 0.81 | ESR1 (0.41) | NR1H2NR1H3PTGDR2NCF1ESR1 | |
| SCHEMBL4013847 | 0.81 | MAPK14 (0.46) | PTGDR2PIK3CDKDM4E | |
| SCHEMBL4012780 | 0.81 | CD38 (0.41) | NR1H2NR1H3ESR1L3MBTL1 | |
| SCHEMBL4299566 | 0.79 | NR1H2 (0.50) | NR1H2NR1H3PTGDR2RXRAPIK3CD | |
| SCHEMBL1124663 | 0.76 | NR1H2 (0.55) | NR1H2NR1H3PPARGESR1 | |
| SCHEMBL16248304 | 0.75 | NCF1 (0.52) | NR1H2NR1H3PTGDR2RXRANCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101541751-A | Quinoline compounds | WYETH CORP (US) | 2009-09-23 | — | — | CN | disclosed |
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |