SCHEMBL4010346

SCHEMBL4010346

COc1ccc(C(N)c2ccc(OC)cc2OC)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.48
CA1 P00915 1/20 0.48
CA2 P00918 1/20 0.48
CA7 P43166 1/20 0.48
CA9 Q16790 1/20 0.48
CA14 Q9ULX7 1/20 0.48
ALDH1A1 P00352 5/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2D6 P10635 3/20 0.46
ADRA2A P08913 2/20 0.46
ADRA1A P35348 2/20 0.46
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
MAPK1 P28482 1/20 0.45
BLM P54132 1/20 0.45
BCHE P06276 1/20 0.44
TYR P14679 1/20 0.44
ACHE P22303 1/20 0.44
HTR2A P28223 1/20 0.44
CYP1A2 P05177 3/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6386316 0.90 BCHE (0.50) CA12CA1CA2CA7CA9
SCHEMBL3140878 0.90 CA1 (0.43) CA12CA1CA2CA7CA9
SCHEMBL4010343 0.90 CA12 (0.43) CA12CA1CA2CA7CA9
SCHEMBL414370 0.90 MEN1 (0.48) CA12CA1CA2CA7CA9
SCHEMBL2632344 0.89 BCHE (0.46) CA12CA1CA2CA7CA9
SCHEMBL11399910 0.89 CA12 (0.56) CA12CA1CA2CA7CA9
SCHEMBL7691614 0.88 MAPK1 (0.47) ALDH1A1CYP3A4CYP2D6ADRA2AADRA1A
SCHEMBL16437139 0.88 CA12 (0.41) CA12CA1CA2CA7CA9
SCHEMBL17189617 0.85 HTR2A (0.42) CA12CA1CA2CA7CA9
SCHEMBL16351174 0.85 SLC2A1 (0.46) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2000004004-A1 METHODS OF SYNTHESIZING SULTAMS AND ANTI-VIRAL COMPOSITIONS THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION (US) 2000-01-27 WO claimed
US-20250084012-A1 METHOD FOR REMOVING TERT-BUTOXYCARBONYL GROUP CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2025-03-13 US disclosed
EP-4461715-A1 METHOD FOR REMOVING TERT-BUTOXYCARBONYL GROUPS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2024-11-13 EP disclosed
US-9598714-B2 Side-chain protected oligopeptide fragment condensation using subtilisins in organic solvents ENZYPEP B.V. (NL) 2017-03-21 US disclosed
US-20150037840-A1 SIDE-CHAIN PROTECTED OLIGOPEPTIDE FRAGMENT CONDENSATION USING SUBTILISINS IN ORGANIC SOLVENTS ENZYPEP B.V. (NL) 2015-02-05 US disclosed
EP-2591795-A1 RNA targeting compounds and methods for making and using same The Research Foundation Of State University Of New York (US) 2013-05-15 EP disclosed
EP-1713493-A4 PITUITARY ADENYLATE CYCLASE ACTIVATING PEPTIDE (PACAP) RECEPTOR (VPAC2) AGONISTS AND THEIR PHARMACOLOGICAL METHODS OF USE BAYER PHARMACEUTICALS CORP (US) 2009-06-24 EP disclosed
US-20090143283-A1 Pituitary Adenylate Cyclase Activating Peptide (PACAP) Receptor (VPAC2) Agonists and Their Pharmacological Methods of Use BAYER PHARMACEUTICALS CORPORATION (US) 2009-06-04 US disclosed
US-20080221303-A1 Method for the Preparation of Peptide-Oligonucleotide Conjugates FRUTAROM LTD. (IL) 2008-09-11 US disclosed
EP-1725250-A2 METHOD FOR THE PREPARATION OF PEPTIDE-OLIGONUCLEOTIDE CONJUGATES FRUTAROM LTD. (IL) 2006-11-29 EP disclosed
EP-1713493-A2 PITUITARY ADENYLATE CYCLASE ACTIVATING PEPTIDE (PACAP) RECEPTOR (VPAC2) AGONISTS AND THEIR PHARMACOLOGICAL METHODS OF USE Bayer Pharmaceuticals Corporation (US) 2006-10-25 EP disclosed
WO-2005076744-A2 METHOD FOR THE PREPARATION OF PEPTIDE-OLIGONUCLEOTIDE CONJUGATES FRUTAROM LTD. (IL) 2005-08-25 WO disclosed
WO-2005072385-A2 PITUITARY ADENYLATE CYCLASE ACTIVATING PEPTIDE (PACAP) RECEPTOR (VPAC2) AGONISTS AND THEIR PHARMACOLOGICAL METHODS OF USE BAYER PHARMACEUTICALS CORPORATION (US) 2005-08-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250084012-A1 METHOD FOR REMOVING TERT-BUTOXYCARBONYL GROUP TERT, MGMT, MITF CA12 1377/4885CA1 2060/4885CA2 1471/4885
US-20080221303-A1 Method for the Preparation of Peptide-Oligonucleotide Conjugates VIP, PTMS, SSTR4 CA12 758/4885CA1 1256/4885CA2 4167/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.