SCHEMBL414370

SCHEMBL414370

COc1ccc(C(N)c2ccccc2)c(OC)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.48
KMT2A Q03164 3/20 0.48
CA12 O43570 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CA7 P43166 1/20 0.46
CA9 Q16790 1/20 0.46
CA14 Q9ULX7 1/20 0.46
ALDH1A1 P00352 2/20 0.44
CYP3A4 P08684 1/20 0.44
HTT P42858 2/20 0.44
MAPT P10636 1/20 0.44
ALOX12 P18054 1/20 0.44
RECQL P46063 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
GAA P10253 1/20 0.44
CYP1A1 P04798 2/20 0.44
CYP1A2 P05177 2/20 0.44
CYP1B1 Q16678 2/20 0.44
CYP2D6 P10635 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4010346 0.90 CA12 (0.48) MEN1KMT2ACA12CA1CA2
SCHEMBL11490700 0.88 GPR88 (0.42) MEN1KMT2AALDH1A1CYP3A4HTT
SCHEMBL3227491 0.86 CYP2D6 (0.50) MEN1KMT2ACA12CA1CA2
SCHEMBL11399910 0.86 CA12 (0.56) MEN1KMT2ACA12CA1CA2
SCHEMBL6386316 0.84 BCHE (0.50) MEN1KMT2ACA12CA1CA2
SCHEMBL3140878 0.84 CA1 (0.43) MEN1KMT2ACA12CA1CA2
SCHEMBL4010343 0.84 CA12 (0.43) MEN1KMT2ACA12CA1CA2
SCHEMBL17871716 0.83 GAA (0.49) MEN1KMT2AALDH1A1GAACYP1A2
SCHEMBL19665104 0.83 ACHE (0.46) MEN1KMT2AALDH1A1CYP3A4MAPT
SCHEMBL28888567 0.83 CA12 (0.48) MEN1KMT2ACA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 176 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3110828-B1 CONTINUOUS FLOW PEPTIDE SYNTHESIS UNIV SZEGEDI (HU) 2020-12-09 EP claimed
EP-3110828-A1 CONTINUOUS FLOW PEPTIDE SYNTHESIS Szegedi Tudományegyetem (HU) 2017-01-04 EP claimed
WO-2015128687-A1 CONTINUOUS FLOW PEPTIDE SYNTHESIS Szegedi Tudományegyetem (HU) 2015-09-03 WO claimed
JP-2273698-A None JP disclosed
JP-2273696-A None JP disclosed
US-12605451-B2 Targeted plasma protein degradation NOVARTIS AG (CH) 2026-04-21 US disclosed
EP-3630147-B1 PEPTIDE PAC1 ANTAGONISTS AMGEN INC (US) 2026-03-25 EP disclosed
EP-4685154-A1 POLYPEPTIDE DERIVED FROM TRIDEGIN Rheinische Friedrich-Wilhelms-Universität Bonn (DE) 2026-01-28 EP disclosed
US-12209144-B2 Cyclic peptides as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors for the treatment of metabolic disorders NOVARTIS AG (CH) 2025-01-28 US disclosed
US-20230398224-A1 TARGETED PLASMA PROTEIN DEGRADATION NOVARTIS AG (CH) 2023-12-14 US disclosed
US-11643440-B2 Peptide PAC1 antagonists AMGEN INC. (US) 2023-05-09 US disclosed
WO-1992022571-A1 IMMUNOASSAY FOR NON-A NON-B HEPATITIS BAXTER DIAGNOSTICS INC. (US) 1992-12-23 WO disclosed
WO-1992017612-A1 ASSAY FOR NON-A NON-B HEPATITIS BAXTER DIAGNOSTICS INC. (US) 1992-10-15 WO disclosed
US-5112947-A Oligopeptides, nootropic agents NIPPON CHEMIPHAR CO., LTD. (JP) 1992-05-12 US disclosed
WO-1992005271-A1 PROCESS FOR THE PREPARATION OF C-TERMINALLY AMIDATED PEPTIDES BUCHARDT OLE (DK) 1992-04-02 WO disclosed
JP-H02273696-A PEPTIDE AND ANTIDEMENTIAL AGENT CONTAINING THE SAME NIPPON CHEMIPHAR CO LTD 1990-11-08 JP disclosed
JP-H02273698-A PEPTIDE AND ANTIDEMENTIAL AGENT CONTAINING THE SAME FUJIREBIO INC 1990-11-08 JP disclosed
EP-0393934-A1 Novel peptides, and antidementia agents containing the same NIPPON CHEMIPHAR CO., LTD. (JP) 1990-10-24 EP disclosed
US-4965343-A COUPLING SIDE-CHAIN UNPROTECTED HYDROXYAMINO ACIDS TO PEPTIDE CHAIN USING BENZOTRIAZOL-1-YL-OXY-TRIS-(DIMETHYL)-OXY-TRIS-(DIMETHYL)-PHOSPHONIUM HEXAFLUOROPHOSPHATE HOFFMANN-LA ROCHE INC. (US) 1990-10-23 US disclosed
US-4478984-A CONDENSING AN N-(CHLOROBENZYL)-PHTHALIMIDE WITH A STYRENE RESIN AND SPLITTING THE IMIDE SMITHKLINE BECKMAN CORPORATION (US) 1984-10-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12605451-B2 Targeted plasma protein degradation M6PR, ASGR1, IGF2R MEN1 1171/4885KMT2A 2504/4885CA12 1734/4885
US-12209144-B2 Cyclic peptides as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors for the treatment of metabolic disorders PCSK9, PCSK7, PCSK6 MEN1 416/4885KMT2A 3479/4885CA12 1554/4885
US-20230398224-A1 TARGETED PLASMA PROTEIN DEGRADATION M6PR, ASGR1, IGF2R MEN1 1297/4885KMT2A 2277/4885CA12 2901/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.