Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4307013 | 0.84 | MMP2 (0.39) | HTTNPSR1TSHRRAB9ASLC6A2 | |
| SCHEMBL4005213 | 0.84 | MAPT (0.40) | PKMNPC1RAB9ASMN1; SMN2ENPP3 | |
| SCHEMBL4009267 | 0.84 | HSD11B1 (0.39) | GAAHTTNPC1RAB9A | |
| SCHEMBL4002524 | 0.84 | EPHX2 (0.48) | GAANPSR1NPC1RAB9A | |
| SCHEMBL4007565 | 0.83 | POLB (0.45) | PKMKDM4ECYP1A2 | |
| SCHEMBL4004677 | 0.83 | KMT2A (0.47) | HDAC3HDAC1HDAC2GAANPC1 | |
| SCHEMBL4004804 | 0.83 | KMT2A (0.47) | HDAC3HDAC1HDAC2GAANPC1 | |
| SCHEMBL4006598 | 0.83 | NPSR1 (0.41) | GAAHTTNPSR1RAB9ACYP2C19 | |
| SCHEMBL4006918 | 0.83 | ALDH1A1 (0.45) | GAANPSR1TSHRSMN1; SMN2ENPP3 | |
| SCHEMBL4006510 | 0.82 | EPHX2 (0.47) | GAAHTTNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | claimed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | claimed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | claimed |