Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4006598 | 0.88 | NPSR1 (0.41) | MMP9KMT2AMEN1RAB9ALMNA | |
| SCHEMBL4009267 | 0.87 | HSD11B1 (0.39) | KMT2AMEN1RAB9AMAPTLMNA | |
| SCHEMBL4010824 | 0.84 | EIF2AK3 (0.46) | RAB9ANPSR1HTTSLC6A2SLC6A4 | |
| SCHEMBL4006918 | 0.84 | ALDH1A1 (0.45) | KMT2ALMNANPSR1ALDH1A1TSHR | |
| SCHEMBL4004804 | 0.84 | KMT2A (0.47) | KMT2AMEN1RAB9AMAPTLMNA | |
| SCHEMBL4004677 | 0.84 | KMT2A (0.47) | KMT2AMEN1RAB9AMAPTLMNA | |
| SCHEMBL4005701 | 0.84 | CXCR2 (0.36) | KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL4006510 | 0.83 | EPHX2 (0.47) | KMT2AMEN1RAB9ALMNAALDH1A1 | |
| SCHEMBL4003899 | 0.83 | EPHX2 (0.49) | KMT2AMEN1LMNAALDH1A1TSHR | |
| SCHEMBL4002524 | 0.82 | EPHX2 (0.48) | KMT2AMEN1RAB9AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |