Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KIF11 | P52732 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | MPL | P40238 | 1/20 | 0.41 |
| ▸ | CDC25A | P30304 | 1/20 | 0.41 |
| ▸ | CDC25C | P30307 | 1/20 | 0.41 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.41 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16510570 | 0.79 | KDM4E (0.61) | ALDH1A1KDM4EHPGDHTTSMN1; SMN2 | |
| SCHEMBL30668529 | 0.78 | KDM4E (0.62) | ALDH1A1KDM4EHPGDHTTSMN1; SMN2 | |
| SCHEMBL852161 | 0.78 | KDM4E (0.62) | ALDH1A1KDM4EHPGDHTTSMN1; SMN2 | |
| SCHEMBL30171433 | 0.75 | ALDH1A1 (0.59) | ALDH1A1KDM4EHPGDHTTSMN1; SMN2 | |
| SCHEMBL2269012 | 0.74 | KDM4E (0.64) | ALDH1A1KDM4EHTTMEN1KMT2A | |
| SCHEMBL14969300 | 0.74 | KDM4E (0.53) | ALDH1A1KDM4EMEN1KMT2AHSD17B10 | |
| SCHEMBL23530348 | 0.74 | KIF11 (0.59) | ALDH1A1KDM4EHPGDHTTSMN1; SMN2 | |
| SCHEMBL237720 | 0.74 | CA12 (0.57) | ALDH1A1KDM4EHPGDHTTSMN1; SMN2 | |
| SCHEMBL29871305 | 0.74 | CA12 (0.57) | ALDH1A1KDM4EHPGDHTTSMN1; SMN2 | |
| SCHEMBL30914261 | 0.72 | KIF11 (0.75) | ALDH1A1KDM4EHPGDHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7485649-B2 | Inhibitors of checkpoint kinases | MERCK & CO., INC. (US) | 2009-02-03 | — | — | US | disclosed |
| US-20080214594-A1 | Inhibitors Of Checkpoint Kinases | MERCK SHARP & DOHME CORP. | 2008-09-04 | — | — | US | disclosed |
| EP-1836807-A2 | INHIBITORS OF CHECKPOINT KINASES | Merck & Co., Inc. (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006074207-A2 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2006-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214594-A1 | Inhibitors Of Checkpoint Kinases | CHEK1, CHEK2, BUB1B | ALDH1A1 3142/4885KDM4E 1025/4885HPGD 3439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.