Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.62 |
| ▸ | HPGD | P15428 | 6/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | KIF11 | P52732 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.44 |
| ▸ | CDC25A | P30304 | 1/20 | 0.43 |
| ▸ | CDC25C | P30307 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MPI | P34949 | 1/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30668529 | 1.00 | KDM4E (0.62) | KDM4EHPGDSMN1; SMN2HTTMAPK1 | |
| SCHEMBL4010927 | 0.78 | ALDH1A1 (0.56) | KDM4EHPGDSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL16510570 | 0.78 | KDM4E (0.61) | KDM4EHPGDSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL28039794 | 0.77 | KDM4E (0.67) | KDM4EHPGDSMN1; SMN2HTTMAPK1 | |
| SCHEMBL18074031 | 0.73 | KDM4E (0.61) | KDM4EHPGDSMN1; SMN2HTTMAPK1 | |
| SCHEMBL28133652 | 0.73 | HPGD (1.00) | KDM4EHPGDSMN1; SMN2HTTMAPK1 | |
| SCHEMBL1173520 | 0.73 | HPGD (1.00) | KDM4EHPGDSMN1; SMN2HTTMAPK1 | |
| SCHEMBL29612166 | 0.73 | HPGD (1.00) | KDM4EHPGDSMN1; SMN2HTTMAPK1 | |
| SCHEMBL23530348 | 0.72 | KIF11 (0.59) | KDM4EHPGDSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL29871305 | 0.72 | CA12 (0.57) | KDM4EHPGDSMN1; SMN2HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107690436-B | Method for forming complexes, complexes and use thereof | 庄信万丰股份有限公司 | 2023-12-22 | — | — | CN | disclosed |
| EP-3303353-B1 | PROCESS | JOHNSON MATTHEY PLC (GB) | 2022-01-12 | — | — | EP | disclosed |
| EP-3303353-B1 | PROCESS | JOHNSON MATTHEY PLC (GB) | 2022-01-12 | — | — | EP | disclosed |
| US-10428098-B2 | Processes for preparing and using ruthenium and osmium complexes | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2019-10-01 | — | — | US | disclosed |
| US-10428098-B2 | Processes for preparing and using ruthenium and osmium complexes | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2019-10-01 | — | — | US | disclosed |
| US-20180169641-A1 | BENZO[H]QUINOLINE LIGANDS AND COMPLEXES THEREOF | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2018-06-21 | — | — | US | disclosed |
| US-20180169641-A1 | BENZO[H]QUINOLINE LIGANDS AND COMPLEXES THEREOF | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2018-06-21 | — | — | US | disclosed |
| US-20180148465-A1 | PROCESS | UNIVERSITA DEGLI STUDI DI UDINE (IT) | 2018-05-31 | — | — | US | disclosed |
| US-20180148465-A1 | PROCESS | UNIVERSITA DEGLI STUDI DI UDINE (IT) | 2018-05-31 | — | — | US | disclosed |
| WO-2016193761-A1 | BENZO[H]QUINOLINE LIGANDS AND COMPLEXES THEREOF | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2016-12-08 | — | — | WO | disclosed |
| US-8440705-B2 | 2,3,4,7,8,9-hexahydro-1H-cyclopenta[h]quinolin-2-one or 2,3,4,6,7,8-hexahydro-1H-cyclopenta[g]quinolin-2-one; Alzheimer's disease | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2013-05-14 | — | — | US | disclosed |
| EP-2433634-A2 | Compounds, compositions and methods of inhibiting a-synuclein toxicity | The Whitehead Institute for Biomedical Research (US) | 2012-03-28 | — | — | EP | disclosed |
| EP-2433634-A2 | Compounds, compositions and methods of inhibiting a-synuclein toxicity | The Whitehead Institute for Biomedical Research (US) | 2012-03-28 | — | — | EP | disclosed |
| CN-102379872-A | Compounds, compositions and methods of inhibiting a-synuclein toxicity | WHITEHEAD BIOMEDICAL INST | 2012-03-21 | — | — | CN | disclosed |
| EP-1802303-B1 | COMPOUNDS, COMPOSITIONS AND METHODS OF INHIBITING A-SYNUCLEIN TOXICITY | WHITEHEAD BIOMEDICAL INST (US) | 2011-11-02 | — | — | EP | disclosed |
| US-20080261953-A1 | Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2008-10-23 | — | — | US | disclosed |
| US-20080261953-A1 | Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2008-10-23 | — | — | US | disclosed |
| CN-101060839-A | Compounds, compositions and methods for inhibiting alpha-synuclein toxicity | WHITEHEAD BIOMEDICAL INST (US) | 2007-10-24 | — | — | CN | disclosed |
| EP-1802303-A2 | COMPOUNDS, COMPOSITIONS AND METHODS OF INHIBITING A-SYNUCLEIN TOXICITY | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006034003-A2 | COMPOUNDS, COMPOSITIONS AND METHODS OF INHIBITING A-SYNUCLEIN TOXICITY | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2006-03-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180169641-A1 | BENZO[H]QUINOLINE LIGANDS AND COMPLEXES THEREOF | BRD4, NQO1, NQO2 | KDM4E 1627/4885HPGD 873/4885SMN1; SMN2 4777/4885 |
| US-20080261953-A1 | Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity | SNCA, PARK7, HTT | KDM4E 1289/4885HPGD 2441/4885SMN1; SMN2 41/4885 |
| US-10428098-B2 | Processes for preparing and using ruthenium and osmium complexes | OSTC, OTC, ORC3 | KDM4E 4260/4885HPGD 2184/4885SMN1; SMN2 4599/4885 |
| US-20180148465-A1 | PROCESS | OSTC, AP2S1, LGALS4 | KDM4E 3554/4885HPGD 2772/4885SMN1; SMN2 4504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.