Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL402118 | 0.83 | RAB9A (0.50) | LMNAEPHX2L3MBTL1NPC1RAB9A | |
| SCHEMBL8429875 | 0.83 | LMNA (0.70) | LMNAEPHX2PPARGL3MBTL1RAB9A | |
| SCHEMBL4237233 | 0.81 | HDAC3 (0.45) | MCHR1NPC1RAB9AALDH1A1POLB | |
| SCHEMBL1096805 | 0.78 | MEN1 (0.46) | MCHR1NPC1RAB9AALDH1A1POLB | |
| SCHEMBL401127 | 0.77 | MCHR1 (0.52) | LMNAEPHX2PPARGMCHR1L3MBTL1 | |
| SCHEMBL6077802 | 0.75 | L3MBTL1 (0.77) | LMNAEPHX2PPARGL3MBTL1ALDH1A1 | |
| SCHEMBL404935 | 0.73 | PLK1 (0.54) | LMNAMCHR1NPC1RAB9AALDH1A1 | |
| SCHEMBL14393711 | 0.72 | LMNA (0.67) | LMNAEPHX2PPARGL3MBTL1NPC1 | |
| SCHEMBL10099594 | 0.72 | LMNA (0.70) | LMNAEPHX2PPARGL3MBTL1ALDH1A1 | |
| SCHEMBL6357065 | 0.72 | LMNA (0.70) | LMNAEPHX2PPARGL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153843-B2 | Antibacterial agents | UNIVERSITY OF WASHINGTON (US) | 2012-04-10 | — | — | US | disclosed |
| US-8101640-B2 | Antibacterial agents | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-20110172174-A1 | Antibacterial agents | NOVARTIS VACCINES AND DIAGNOSTICS INC. | 2011-07-14 | — | — | US | disclosed |
| US-20100324025-A1 | Antibacterial Agents | UNIVERSITY OF WASHINGTON (US) | 2010-12-23 | — | — | US | disclosed |
| US-20090247506-A1 | Antibacterial agents | CHIRON CORPORATION | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247506-A1 | Antibacterial agents | MRPL21, SI, PGLS | LMNA 3397/4885EPHX2 2566/4885PPARG 1875/4885 |
| US-20110172174-A1 | Antibacterial agents | MRPL21, SI, PGLS | LMNA 3397/4885EPHX2 2566/4885PPARG 1875/4885 |
| US-20100324025-A1 | Antibacterial Agents | MRPL21, SI, PGLS | LMNA 3397/4885EPHX2 2566/4885PPARG 1875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.