Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.41 |
| ▸ | CDK9 | P50750 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 6/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4017565 | 0.85 | NR1H2 (0.47) | CCNT1CDK9PTGDR2PDE4BALDH1A1 | |
| SCHEMBL4013308 | 0.83 | HTR1A (0.47) | CCNT1CDK9SRCPTGDR2PDE4B | |
| SCHEMBL4020656 | 0.81 | PTGDR2 (0.41) | LRRK2PTGDR2ARALDH1A1MAPT | |
| SCHEMBL4015117 | 0.81 | NR1H2 (0.62) | SCN9ANR1H2NR1H3 | |
| SCHEMBL4013857 | 0.80 | NR1H2 (0.47) | CCNT1CDK9PTGDR2MAPTRAB9A | |
| SCHEMBL27786981 | 0.79 | CCNT1 (0.43) | CCNT1CDK9SRCPTGDR2ABL1 | |
| SCHEMBL4011482 | 0.78 | NR1H2 (0.47) | CCNT1CDK9PTGDR2PDE4BALDH1A1 | |
| SCHEMBL317372 | 0.73 | KDM4E (0.49) | LRRK2PTGDR2ARALDH1A1MAPT | |
| SCHEMBL4016936 | 0.69 | HTR1A (0.46) | PTGDR2PDE4BALDH1A1MAPTMEN1 | |
| SCHEMBL4013386 | 0.69 | PTGDR2 (0.39) | CCNT1CDK9PTGDR2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |