Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.44 |
| ▸ | CDK9 | P50750 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.40 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4017565 | 0.89 | NR1H2 (0.47) | CCNT1CDK9ALDH1A1MEN1KMT2A | |
| SCHEMBL4016936 | 0.86 | HTR1A (0.46) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL4013386 | 0.84 | PTGDR2 (0.39) | HTR1AADRA1DADRA1AADRA1BCCNT1 | |
| SCHEMBL4016946 | 0.84 | HTR1A (0.47) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL4013857 | 0.84 | NR1H2 (0.47) | CCNT1CDK9MAPTRAB9APTGDR2 | |
| SCHEMBL4011959 | 0.83 | LRRK2 (0.42) | CCNT1CDK9ALDH1A1MEN1MAPT | |
| SCHEMBL4011491 | 0.83 | NR1H2 (0.64) | CDK9CLK4NR1H2NR1H3 | |
| SCHEMBL4011482 | 0.82 | NR1H2 (0.47) | CCNT1CDK9ALDH1A1POLBMEN1 | |
| SCHEMBL4010720 | 0.81 | NR1H2 (0.52) | HTR1AADRA1DADRA1AADRA1BPOLB | |
| SCHEMBL4012811 | 0.80 | NR1H2 (0.53) | HTR1AADRA1DADRA1AADRA1BCCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |