Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | HTR2B | P41595 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SCN4A | P35499 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14312071 | 0.85 | SSTR4 (0.53) | LMNASMN1; SMN2HPGDTSHRSLC6A4 | |
| SCHEMBL2299930 | 0.85 | LMNA (0.45) | LMNASMN1; SMN2HPGDTSHRPOLB | |
| SCHEMBL23466495 | 0.79 | HTR2C (0.56) | HTR2CHTR2BLMNASMN1; SMN2HPGD | |
| SCHEMBL19962876 | 0.79 | ALDH1A1 (0.47) | LMNASMN1; SMN2HPGDPOLBMAPK1 | |
| SCHEMBL31063296 | 0.79 | NPC1 (0.54) | HTR2CHTR2BLMNASMN1; SMN2SLC6A4 | |
| SCHEMBL29757994 | 0.79 | HTR2C (0.56) | HTR2CHTR2BLMNASMN1; SMN2HPGD | |
| SCHEMBL17366258 | 0.79 | SSTR4 (0.43) | HTR2CHTR2BHPGDALDH1A1MEN1 | |
| SCHEMBL2561303 | 0.79 | NOS3 (0.44) | HTR2CHTR2BHPGDALDH1A1 | |
| SCHEMBL22693816 | 0.78 | PDE4B (0.43) | HTR2CHTR2BSMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL24334343 | 0.78 | KDM4E (0.54) | HTR2CHTR2BLMNASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009010560-A1 | PYRAZOLE DERIVATIVES AND USE THEREOF AS INHIBITORS OF STEAROYL-COA DESATURASE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-01-22 | — | — | WO | disclosed |
| WO-2009010560-A1 | PYRAZOLE DERIVATIVES AND USE THEREOF AS INHIBITORS OF STEAROYL-COA DESATURASE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-01-22 | — | — | WO | disclosed |