Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5475421 | 1.00 | SHMT2 (0.40) | SHMT2TSHRL3MBTL1CA12CA1 | |
| SCHEMBL674245 | 0.88 | — | — | |
| SCHEMBL17892734 | 0.72 | RYR2 (0.53) | SHMT2 | |
| SCHEMBL6225796 | 0.68 | MAPT (0.47) | TSHRHTR1AADRA2ASLC6A2SLC6A4 | |
| SCHEMBL31001735 | 0.68 | ALDH1A1 (0.36) | SHMT2TSHR | |
| SCHEMBL1399871 | 0.68 | — | — | |
| SCHEMBL15539282 | 0.68 | ALDH1A1 (0.36) | SHMT2TSHR | |
| SCHEMBL2511410 | 0.68 | HPGD (0.40) | — | |
| SCHEMBL170259 | 0.68 | SIGMAR1 (0.33) | — | |
| SCHEMBL26871373 | 0.67 | HRH1 (0.36) | SHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | claimed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | claimed |