Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3592846 | 0.84 | TMEM97 (0.54) | MEN1KMT2AGRM5SMN1; SMN2HTR1A | |
| SCHEMBL18586080 | 0.82 | GRM5 (0.52) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL27857403 | 0.81 | HTR1A (0.50) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL7914920 | 0.81 | PRMT6 (0.59) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL4181983 | 0.80 | AGXT (0.60) | HTR2AHTR6 | |
| SCHEMBL10237108 | 0.79 | PRMT6 (0.62) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL14830657 | 0.79 | ITGB3 (0.48) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL5763718 | 0.78 | DRD2 (0.60) | MAPTTSHRLMNAUSP2MAPK1 | |
| SCHEMBL10237111 | 0.77 | AGXT (0.60) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL5762489 | 0.77 | DRD2 (0.62) | MAPTALDH1A1HTR1AHTR7HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074127-A1 | PYRAZOLO [1, 5-A]PYRIMIDINE DERIVATIVES AND THEIR THERAPEUTIC USE | Novartis AG (CH) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008037459-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AND THEIR THERAPEUTIC USE | NOVARTIS AG (CH) | 2008-04-03 | — | — | WO | disclosed |