Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | GRM5 | P41594 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28322328 | 0.89 | AKR1C3 (0.54) | HTR1AHTR7ITGB3ITGA2BHTR2A | |
| SCHEMBL14830657 | 0.88 | ITGB3 (0.48) | HTR1AHTR7ITGB3ITGA2BHTR2A | |
| SCHEMBL24677569 | 0.87 | MEN1 (0.51) | HTR1AHTR7HTR2AHTR6MEN1 | |
| SCHEMBL18586080 | 0.86 | GRM5 (0.52) | HTR1AHTR7ITGB3ITGA2BHTR2A | |
| SCHEMBL27662780 | 0.85 | AGXT (0.56) | ITGB3ITGA2BSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL110127 | 0.84 | POLB (0.50) | ITGB3ITGA2BMEN1KMT2AALDH1A1 | |
| SCHEMBL10282747 | 0.82 | MEN1 (0.53) | HTR1AHTR7MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27642212 | 0.82 | LMNA (0.47) | HTR1AHTR7ITGB3ITGA2BHTR2A | |
| SCHEMBL4014464 | 0.81 | MAPT (0.49) | HTR1AHTR7ITGB3ITGA2BHTR2A | |
| SCHEMBL3119833 | 0.81 | ADRA2C (0.59) | HTR1AHTR7HTR2AHTR6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102015668-A | Piperazine derivatives and their use as leptin receptor modulators | ASTRAZENECA AB PUBL | 2011-04-13 | — | — | CN | disclosed |