Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | L3MBTL3 | Q96JM7 | 6/20 | 0.47 |
| ▸ | MBTD1 | Q05BQ5 | 5/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.45 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21766914 | 0.85 | CYP2D6 (0.65) | CYP2D6CYP1A2ALDH1A1POLBL3MBTL3 | |
| SCHEMBL13645932 | 0.81 | CYP1A2 (0.69) | CYP2D6CYP1A2ALDH1A1POLBL3MBTL3 | |
| SCHEMBL4018680 | 0.81 | CYP1A2 (0.69) | CYP2D6CYP1A2ALDH1A1POLBL3MBTL3 | |
| SCHEMBL13475706 | 0.80 | CYP1A2 (0.65) | CYP2D6CYP1A2ALDH1A1POLBL3MBTL3 | |
| SCHEMBL8149995 | 0.80 | CYP1A2 (0.67) | CYP2D6CYP1A2ALDH1A1POLBL3MBTL3 | |
| SCHEMBL4993839 | 0.79 | CYP1A2 (0.67) | CYP2D6CYP1A2ALDH1A1POLBL3MBTL3 | |
| SCHEMBL4023975 | 0.78 | CYP1A2 (0.65) | CYP2D6CYP1A2ALDH1A1POLBL3MBTL3 | |
| SCHEMBL4018355 | 0.77 | CYP1A2 (1.00) | CYP2D6CYP1A2ALDH1A1POLBMGLL | |
| SCHEMBL31323039 | 0.75 | SMN1; SMN2 (0.66) | CYP2D6CYP1A2ALDH1A1POLBL3MBTL3 | |
| SCHEMBL13973363 | 0.75 | L3MBTL3 (0.65) | ALDH1A1L3MBTL3MBTD1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514418-B2 | Camptothecin analogs and methods of preparation thereof | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2009-04-07 | — | — | US | disclosed |
| US-7514418-B2 | Camptothecin analogs and methods of preparation thereof | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2009-04-07 | — | — | US | disclosed |
| US-20070259905-A1 | Camptothecin analogs and methods of preparation thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-11-08 | — | — | US | disclosed |
| US-6150343-A | 10-HYDROXY-7-SUBSTITUTED SILYLCAMPTOTHECIN DERIVATIVE IS USED AS ANTICARCINOGENIC AND ANTITUMOR AGENT | UNIVERSITY OF PITTSBURGH (US) | 2000-11-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259905-A1 | Camptothecin analogs and methods of preparation thereof | ADCY9, BCL9, ADCY10 | CYP2D6 619/4885CYP1A2 703/4885ALDH1A1 1767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.